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23-060M IKKγ

IKKγ : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Key Applications: Enzyme Assays
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23-060M
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Key ApplicationsSpeciesCascade Component
      Enzyme AssaysHuman Substrate
      Description
      Catalogue Number23-060M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionIKKγ
      Alternate Names
      • NF-kappa-B essential modulator. Inhibitor of nuclear factor kappa-B kinase subunit gamma
      • FIP-3
      • NEMO
      • IKKg
      Background InformationIKKγ has been shown to play a critical role in NF-κB activation, as the regulatory subunit of IκB kinase, which phosphorylates inhibitors of NF-κB leading to their degradation. Upon cell stimulation, IKKγ can be modified by Lys-63-linked or linear polyubiquitination, both of which are suggested to play key roles in cell signalling, including NF-κB activation. One of the E3 ligases responsible for Lys-63-linked IKKγ polyubiquitination is TRAF6, which participates in several signalling pathways controlling immunity, skin development, osteoclast formation and brain functions.
      References
      Product Information
      Quality LevelMQ100
      Applications
      Key Applications
      • Enzyme Assays
      Biological Information
      Cascade ComponentSubstrate
      Entrez Gene Number
      Purification MethodPurified using glutathione sepharose.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material SizeBULK
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      23-060M 04053252959486

      Produits & Applications associés

      Alternative Packsize

      Référence Description  
      23-060 IKKγ Prix & Disponibilité

      Familles de produits

      Ubiquitin Proteasome System: Enzymes and Substrates

      Millipore has removed the complexity of Ubiquitination by providing functionally validated enzymes and substrates, making the pathway readily accessible for research and drug discovery.
      En savoir plus >>

      Catégories

      Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitin E3 Ligases
      Life Science Research > Proteins and Enzymes > Ubiquitin E3 Ligases