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508313 HSP90α Inhibitor, PU-29F - CAS 422508-27-8 - Calbiochem

A cell-permeable 6-amino-purine based compound that selectively binds to HSP90a (EC₅₀ = 5.4 µM) and inhibits its activity cancer cells.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 2-Fluoro-9-(2-isopropoxyethyl)-8-(3,4,5-trimethoxybenzyl)-9H-purin-6-amine

Primary Target: HSP90a
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508313
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Aperçu

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Tableau de caractéristiques principal

CAS #Empirical Formula
422508-27-8C₂₀H₂₆FN₅O₄

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      Description
      OverviewA cell-permeable 6-amino-purine based compound that selectively binds to HSP90a (EC50 = 5.4 µM) and inhibits its activity in SKBr3 and MCF-7 breast cancer cells. Exhibits much reduced activity towards other paralogs (EC50 = 22.85, 71, and 173 5.4 µM for HSP90b, GRP94 AND Trap-1, respectively). Selectively depletes cytosolic HER2 and induces its redistribution towards lysosomes and early endosomes (~20 5.4 µM) without affecting membrane associated HER2. Does not appear to be toxic towards nonmalignant cells.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number508313
      Brand Family Calbiochem®
      Synonyms2-Fluoro-9-(2-isopropoxyethyl)-8-(3,4,5-trimethoxybenzyl)-9H-purin-6-amine
      References
      ReferencesPatel, P.D., et al. 2013. Nat. Chem. Biol.9, 677.
      Product Information
      CAS number422508-27-8
      FormOff-white powder
      Hill FormulaC₂₀H₂₆FN₅O₄
      Chemical formulaC₂₀H₂₆FN₅O₄
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHSP90a
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5083130001 04055977261813

      Documentation

      HSP90α Inhibitor, PU-29F - CAS 422508-27-8 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Patel, P.D., et al. 2013. Nat. Chem. Biol.9, 677.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-April-2014 JSW
      Synonyms2-Fluoro-9-(2-isopropoxyethyl)-8-(3,4,5-trimethoxybenzyl)-9H-purin-6-amine
      DescriptionA cell-permeable 6-amino-purine based compound that selectively binds to HSP90a (EC50 = 5.4 µM) and inhibits its activity in SKBr3 and MCF-7 breast cancer cells. Exhibits much reduced activity towards other paralogs (EC50 = 22.85, 71, and 173 5.4 µM for HSP90b, GRP94 AND Trap-1, respectively). Selectively depletes cytosolic HER2 and induces its redistribution towards lysosomes and early endosomes (~20 5.4 µM) without affecting membrane associated HER2. Does not appear to be toxic towards nonmalignant cells.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number422508-27-8
      Chemical formulaC₂₀H₂₆FN₅O₄
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPatel, P.D., et al. 2013. Nat. Chem. Biol.9, 677.