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397100 HNMPA-(AM)₃ - CAS 120944-03-8 - Calbiochem

A cell-permeable analog of HNMPA that yields the parent compound upon cleavage by cytosolic esterases.

HNMPA-(AM)₃ - CAS 120944-03-8 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Hydroxy-2-naphthalenylmethylphosphonic Acid Trisacetoxymethyl Ester, Pro-drug II

Primary Target: tyrosine kinase
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397100
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
120944-03-8C₂₀H₂₃O₁₀P

Prix & Disponibilité

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397100-5MG
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      		 Ampoule plast. 5 mg
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      Description
      OverviewA cell-permeable analog of HNMPA that yields the parent compound upon cleavage by cytosolic esterases. Inhibits insulin receptor tyrosine kinase (IC50 = 100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50 = 10 µM). Also reported to inhibit tyrosine autophosphorylation of the human insulin receptor (IC50 = 200 µM).
      Catalogue Number397100
      Brand Family Calbiochem®
      SynonymsHydroxy-2-naphthalenylmethylphosphonic Acid Trisacetoxymethyl Ester, Pro-drug II
      References
      ReferencesBaltensperger, K., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 7885.
      Saperstein, R., et al. 1989. Biochemistry 28, 5694.
      Product Information
      CAS number120944-03-8
      ATP CompetitiveN
      FormColorless oil
      Hill FormulaC₂₀H₂₃O₁₀P
      Chemical formulaC₂₀H₂₃O₁₀P
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targettyrosine kinase
      Primary Target IC<sub>50</sub>100 µM and 10 µM against insulin receptor tyrosine kinase and insulin-stimulated glucose oxidation in isolated rat adipocytes, respectively
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      397100-5MG 04055977212549

      Documentation

      HNMPA-(AM)₃ - CAS 120944-03-8 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      HNMPA-(AM)₃ - CAS 120944-03-8 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      397100

      Références bibliographiques

      Aperçu de la référence bibliographique
      Baltensperger, K., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 7885.
      Saperstein, R., et al. 1989. Biochemistry 28, 5694.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsHydroxy-2-naphthalenylmethylphosphonic Acid Trisacetoxymethyl Ester, Pro-drug II
      DescriptionA cell-permeable analog of HNMPA. Inhibits insulin receptor tyrosine kinase (IC50 = 100 mM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50 = 10 µM). Also reported to inhibit tyrosine autophosphorylation of the human insulin receptor (IC50 = 200 µM). It has no effect on PKA (at concentrations up to 1 mM) or PKC (at concentrations up to 420 µM).
      FormColorless oil
      CAS number120944-03-8
      Chemical formulaC₂₀H₂₃O₁₀P
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (20 mg/ml) or Ethanol (20 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBaltensperger, K., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 7885.
      Saperstein, R., et al. 1989. Biochemistry 28, 5694.