345887 Sigma-AldrichGinkgolic Acid (15:1) - CAS 22910-60-7 - Calbiochem
Ginkgolic Acid (15:1), CAS 22910-60-7, is a cell-permeable analog of anacardic acid that inhibits protein SUMOylation (IC50 = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner.
More>> Ginkgolic Acid (15:1), CAS 22910-60-7, is a cell-permeable analog of anacardic acid that inhibits protein SUMOylation (IC50 = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: Histone Acetyltransferase Inhibitor VI, PCAF Inhibitor II, SUMOylation Inhibitor, (Z)-6-(Pentadec-8-enyl)-2-hydroxybenzoic acid, HAT Inhibitor VI
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Aperçu
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
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| 22910-60-7 | C₂₂H₃₄O₃ |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
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| 345887-5MG |
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Ampoule plast. | 5 mg |
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| Description | |
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| Overview | A cell-permeable anacardic acid (Cat. No. 172050) analog that inhibits protein SUMO (Cat. Nos. 662037, 662039, and 662042) modification (IC50 = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. Nos. 662073 and 662074) and interfering with E1-SUMO intermediate formation independent of E1 active site cysteine. Both ginkgolic acid and anacardic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins, including p53, in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although both compounds are shown to inhibit histone lysine acetylation by PCAF (Cat. No. 124026) in cell-free acetylase assays. Also available as a 25 mM solution in DMSO (Cat. No. 508197). |
| Catalogue Number | 345887 |
| Brand Family | Calbiochem® |
| Synonyms | Histone Acetyltransferase Inhibitor VI, PCAF Inhibitor II, SUMOylation Inhibitor, (Z)-6-(Pentadec-8-enyl)-2-hydroxybenzoic acid, HAT Inhibitor VI |
| References | |
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| References | Fukuda, I., et al. 2009. Chem. Biol. 16, 133. |
| Product Information | |
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| CAS number | 22910-60-7 |
| Form | White solid |
| Hill Formula | C₂₂H₃₄O₃ |
| Chemical formula | C₂₂H₃₄O₃ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
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| Purity | ≥98% by HPLC |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information | |
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| R Phrase | R: 36/37/38 Irritating to eyes, respiratory system and skin. |
| S Phrase | S: 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 345887-5MG | 04055977214543 |
Documentation
Ginkgolic Acid (15:1) - CAS 22910-60-7 - Calbiochem FDS
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Ginkgolic Acid (15:1) - CAS 22910-60-7 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 345887 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Fukuda, I., et al. 2009. Chem. Biol. 16, 133. |