324623 Sigma-AldrichEg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem
The Eg5 Inhibitor IV, VS-83, also referenced under CAS 909250-29-9, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The Eg5 Inhibitor IV, VS-83, also referenced under CAS 909250-29-9, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: 5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione
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Aperçu
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
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| 909250-29-9 | C₁₄H₁₁FN₂OS |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
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| 324623-5MG |
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Flacon en verre | 5 mg |
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| Description | |
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| Overview | A cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC50 = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC50 = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells. |
| Catalogue Number | 324623 |
| Brand Family | Calbiochem® |
| Synonyms | 5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione |
| References | |
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| References | Muller, C., et al. 2007. Cancer Chemother. Pharmacol. 59, 157. Santamaria, A., et al. 2007. Mol. Biol. Cell 18, 4024. Sarli, V., et al. 2005. ChemBioChem 6, 2005. |
| Product Information | |
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| CAS number | 909250-29-9 |
| Form | White solid |
| Hill Formula | C₁₄H₁₁FN₂OS |
| Chemical formula | C₁₄H₁₁FN₂OS |
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| Quality Level | MQ100 |
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| Purity | ≥99% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 324623-5MG | 04055977197389 |
Documentation
Eg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem FDS
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Références bibliographiques
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| Muller, C., et al. 2007. Cancer Chemother. Pharmacol. 59, 157. Santamaria, A., et al. 2007. Mol. Biol. Cell 18, 4024. Sarli, V., et al. 2005. ChemBioChem 6, 2005. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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