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324411 Dynamin Inhibitor II, MiTMAB - CAS 1119-97-7 - Calbiochem

The Dynamin Inhibitor II, MiTMAB, also referenced under CAS 1119-97-7, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Tetradecyltrimethylammonium Bromide, Myristyltrimethylammonium Bromide, TTAB

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324411
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Tableau de caractéristiques principal

CAS #Empirical Formula
1119-97-7C₁₇H₃₈NBr

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324411-500MG
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      Description
      OverviewA cell-permeable cationic surfactant that reversibly inhibits dynamin GTPase activity (IC50 = 3.15 µM) by targeting the PH domain and interfering with phospholipid binding. Shown to block dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP.
      Catalogue Number324411
      Brand Family Calbiochem®
      SynonymsTetradecyltrimethylammonium Bromide, Myristyltrimethylammonium Bromide, TTAB
      References
      ReferencesQuan, A., et al. 2007. Mol. Pharmacol. 72, 1425.
      Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett. 14, 3275.
      Product Information
      CAS number1119-97-7
      FormWhite solid
      Hill FormulaC₁₇H₃₈NBr
      Chemical formulaC₁₇H₃₈NBr
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by Titration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 34

      Causes burns.
      S PhraseS: 26-36/37/39-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Corrosive
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      324411-500MG 04055977197174

      Documentation

      Dynamin Inhibitor II, MiTMAB - CAS 1119-97-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Dynamin Inhibitor II, MiTMAB - CAS 1119-97-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      324411

      Références bibliographiques

      Aperçu de la référence bibliographique
      Quan, A., et al. 2007. Mol. Pharmacol. 72, 1425.
      Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett. 14, 3275.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-April-2008 JSW
      SynonymsTetradecyltrimethylammonium Bromide, Myristyltrimethylammonium Bromide, TTAB
      DescriptionA cell-permeable cationic surfactant that reversibly inhibits dynamin GTPase activity (IC50 = 3.15 µM) by targeting the PH domain and interfering with phospholipid binding. Shown to block dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1119-97-7
      Chemical formulaC₁₇H₃₈NBr
      Purity≥99% by Titration
      SolubilityDMSO (10 mg/ml) or H₂O (100 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Corrosive
      Merck USA index14, 6336
      ReferencesQuan, A., et al. 2007. Mol. Pharmacol. 72, 1425.
      Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett. 14, 3275.