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138001 D-Amino Acid Oxidase Inhibitor II, CBIO - CAS 61977-29-5 - Calbiochem

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CAS #Empirical Formula
61977-29-5C₇H₄ClNO₂

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138001-50MG
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      Description
      OverviewA cell-permeable benzisoxazolone compound that potently inhibits D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) activity (IC50 = 90 and 150/188 nM against rat spinal cord and porcine kidney DAO, respectively) in a reversible and D-serine-competitive (Ki = 100 nM) manner. Upon co-administration, CBIO (30 mg/kg, p.o.) markedly prolongs the half-life of orally administered D-serine (30 mg/kg) in plasma, resulting in enhanced rat brain D-serine level (60% vs. 25% above basal, respectively, with vs. without CBIO). Direct intrathecal/spinal CBIO injection either before (ED50 =60 ng) or after (ED50 = 170 ng) subcutaneous formalin injection (50 µl 5% solution) greatly alleviates formalin-induced late phase tonic pain (Emax =67%), but not early phase acute nociception in rats in vivo.
      Catalogue Number138001
      Brand Family Calbiochem®
      Synonyms6-Chloro-1,2-benzisoxazol-3(2H)-one, 6-Chlorobenzo[d]isoxazol-3-ol, D-AAO Inhibitor II, CBIO
      References
      ReferencesGong, N., et al. 2011. J. Pharmacol. Exp. Ther. 336, 282.
      Ferraris, D., et al. 2008. J. Med. Chem. 51, 3357.
      Product Information
      CAS number61977-29-5
      FormOff-white powder
      Hill FormulaC₇H₄ClNO₂
      Chemical formulaC₇H₄ClNO₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥97% by HPLC
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      138001-50MG 04055977222319