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15-206 BACE Proteins Investigator Minipack

This Antibody pack contains Anti-BACE Antibody, Anti-BACE2 Antibody, Anti-BACE Antibody C-terminus.

Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: ASP2, BACE, EC 3.4.23.46 , FLJ90568, HSPC104, KIAA1149, Memapsin-2, beta-secretase UniProt Number: Q9Y5Z0, P56817
15-206
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      Description
      Catalogue Number15-206
      DescriptionBACE Proteins Investigator Minipack
      Alternate Names
      • ASP2
      • BACE1
      • Beta Secretase
      • beta-Site APP Cleaving Enzyme
      • Aspartyl protease 2
      • Beta-site amyloid precursor protein cleaving enzyme 1
      • Membrane-associated aspartic protease 2
      • beta-site amyloid beta A4 precursor protein-cleaving enzyme
      • beta-site amyloid precursor protein cleaving enzyme 2
        transmembrane aspartic proteinase Asp2
      Background InformationPathway Investigator Antibody MiniPack:
      Each Pathway Explorer Antibody Minipack contains three related antibodies as part of a signaling cascade or a combination of total and phosphorylated forms of key signaling targets. Each of the three antibodies are 30% the original pack size. Full size versions of each of the Pathway Explorer antibodies are available for sale individually under the same catalog number with the removal of “SP” off of each one (e.g. 05-591SP can be ordered as 05-591).

      Anti-BACE:
      BACE is an N-glycosylated integral membrane aspartyl protease with Mr=70 kDa. Mature BACE is produced from the immature form through a series of post-translational proteolytic cleavages and glycosylation. Sequence analysis has revealed that the immature form of BACE contains an N-terminal signal sequence (residues 1-21) followed by a large catalytic domain, a single transmembrane domain (residues 461-477), and a short cytoplasmic domain (residues 478-501). The signal sequence (1-21) is cleaved from the immature form by a signal peptidase located in the endoplasmic reticulum (ER), yielding the proBACE protein (Mr=75 kDa) which starts at residue 22. The proBACE protein is modified by cleavage of 24 N-terminal residues (aa 22-45), producing the mature BACE protein.

      Anti-BACE2:
      Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer’s disease and a frequent complication of Down syndrome. BACE2 proteolytically cleaves amyloid precursor protein, generating the amyloid beta peptide. BACE2 is a member of the peptidase A1 protein family, a type I integral membrane glycoprotein and aspartic protease.

      Anti-BACE, C-terminus, clone 61-3E7:
      Alzheimer's disease (AD) is characterized by the progressive formation in the brain of insoluble amyloid plaques and vascular deposits consisting of the 4-kD amyloid b-peptide (Ab). Ab generation is initiated by proteolytic cleavage of the amyloid precursor protein (APP) at the N-terminal of Ab by b-secretase. The Ab peptide is then released by proteolytic cleavage at its C-terminus by g-secretase. Because both these proteases are prime candidates for therapeutic intervention, an intense search has been underway to identify these two enzymes. A human transmembrane aspartic-protease (Asp2), referred to as BACE, has been characterized and shown to have all the properties of b-secretase. Four groups in all have now confirmed that BACE (or Asp2) is a convincing candidate for b-secretase. BACE is an N-glycosylated integral membrane aspartyl protease with Mr=70 kDa. Mature BACE is produced from the immature form through a series of post-translational.

      * See full size versions for corresponding references.
      References
      Product Information
      Components
      • AB5940SP Anti-BACE
      • AB9574SP Anti-BACE2
      • MAB5308SP Anti-BACE, C-terminus, clone 61-3E7
      Presentation3 individual tubes containing either Anti-BACE; Anti-BACE2; or Anti-BACE, C-terminus, clone 61-3E7
      PropertiesEach vial is 30% the size of the parent catalog number
      Quality LevelMQ100
      Applications
      ApplicationThis Antibody pack contains Anti-BACE Antibody, Anti-BACE2 Antibody, Anti-BACE Antibody C-terminus.
      Biological Information
      Entrez Gene Number
      Gene Symbol
      • ASP2
      • BACE
      • EC 3.4.23.46
      • FLJ90568
      • HSPC104
      • KIAA1149
      • Memapsin-2
      • beta-secretase
      UniProt Number
      UniProt SummaryBACE1:
      FUNCTION: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
      CATALYTIC ACTIVITY: Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
      ENZYME REGULATION: Inhibited by RTN3 and RTN4.
      SUBUNIT: Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      ALTERNATIVE PRODUCTS: 4 named isoforms [FASTA] produced by alternative splicing.
      TISSUE SPECIFICITY: Brain.
      SIMILARITY: Belongs to the peptidase A1 family

      BACE2:
      CATALYTIC ACTIVITY: Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
      SUBUNIT: Interacts ith RTN3 and RTN4.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: Belongs to the peptidase A1 family [view classification].
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size3 vials/Pk
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      15-206 04053252001055

      Documentation