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MABN824 Anti-α-syn Antibody (amino acids 115-122), clone LB509

MABN824
100 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN824
      DescriptionAnti-α-syn Antibody (amino acids 115-122), clone LB509
      Alternate Names
      • Alpha-synuclein
      • Non-A beta component of AD amyloid
      • Non-A4 component of amyloid precursor
      • NACP
      Background Informationalpha-Synuclein is a small (140 amino acid) cytoplasmic protein of unclear function that is enriched in presynaptic terminals and is the precursor protein of a nonamyloid beta component of senile plaques in Alzeheimer's Disease (AD). α-Synuclein is located predominantly in the presynaptic nerve terminals in the brain but is also found in low concentrations in all tissues except liver. Studies have shown that abnormal aggregation and accumulation of synaptic proteins, including α-Synuclein, might be associated with plaque formation in AD and a major component of Lewy bodies in dementia with Lewy bodies (DLB). It has also been identified in the Glial Cytoplasmic Inclusions (GCIs) found in Multiple System Atrophy (MSA). Clone LB509 detects epitope in the region from amino acid 115 to 122 and has been used to characterize the digestion patterns of different forms of in vitro prepared alpha-synclulein aggregates (Guo, J.L., et al. 2013; PMID 23827677).
      Product Information
      FormatPurified
      HS Code3002 15 90
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationAnti-α-syn Antibody (amino acids 115-122), clone LB509 is an antibody against α-syn for use in Western Blotting and Immunohistochemistry.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected α-syn in human cerebral cortex tissue.
      Western Blotting Analysis: A representative lot detected α-syn in PK-digested FL a-syn pffs (Guo, J.L., et al. (2013). Cell. 154:103-117).
      Biological Information
      ImmunogenConjugated linear peptide corresponding to human α-syn (aa 115-122).
      CloneLB509
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityThis antibody detects a-Synuclein preformed fibrils that can cross seed tau fibrilliation.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SNCA
      • NACP
      • PARK1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~15 kDa observed
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human brain tissue lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected α-syn in 10 µg of human brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Référence GTIN
      MABN824 04055977144970