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07-2117 Anti-phospho-RSK1/2 Antibody (Ser363) (Turn motif)

This phospho-RSK1/2 antibody is validated for use in WB for the detection of the phospho-RSK1/2 protein.

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Research Category: Signaling Research Sub-Category: Kinases & Phosphatases Gene Symbol: RPS6KA1, MAPKAPK1A, RSK1 UniProt Number: Q15418
07-2117
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, XnWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-2117
      DescriptionAnti-phospho-RSK1/2 Antibody (Ser363) (Turn motif)
      Alternate Names
      • Ribosomal protein S6 kinase alpha-1
      • S6K-alpha-1
      • 90 kDa ribosomal protein S6 kinase 1
      • p90-RSK 1
      • p90RSK1
      • p90S6K
      • MAP kinase-activated protein kinase 1a
      • MAPK-activated protein kinase 1a
      • MAPKAP kinase 1a
      • MAPKAPK-1a
      • Ribosomal S6 kinase 1
      • RSK-1
      Background InformationP90 ribosomal S6 kinase 1 and 2 (RSK1 and RSK2) belong to a family of Ser/Thr kinases that are important for cell cycle, survival, proliferation and other cellular functions. RSK isoforms are made up of two kinase domains and seem to be activated sequentially by a number of phosphorylation events. RSK1 and RSK2 have both been found to be over-expressed in certain cancer types and both could be promising as cancer treatments. RSK2 has recently been implicated in oncogenesis and tumor progression. RSK1 interacts with PKARIalpha through the N-terminal kinase domain and regulates protein kinase A.
      References
      Product Information
      FormatAffinity Purified
      Control
      • EGF treated A431 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis phospho-RSK1/2 antibody is validated for use in WB for the detection of the phospho-RSK1/2 protein.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human RSK1/2 phosphorylated at (Ser363).
      EpitopePhosphorylated Ser363 of the AGC-kinase C-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes RSK1/2 phosphorylated at (Ser363).
      Species Reactivity
      • Human
      • Xenopus
      Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Zebra Fish and Xenopus based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
      Gene Symbol
      • RPS6KA1
      • MAPKAPK1A
      • RSK1
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.

      CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

      COFACTOR: Magnesium.

      ENZYME REGULATION: Activated by multiple phosphorylations on threonine and serine residues.

      SUBUNIT STRUCTURE: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.

      PTM: Autophosphorylated on Ser-380, as part of the activation process.

      SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

      Contains 1 AGC-kinase C-terminal domain.

      Contains 2 protein kinase domains.
      Molecular Weight~80 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in EGF treated A431 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected RSK1/2 on 10 µg of EGF treated A431 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      07-2117 04053252292576

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      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies