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MAB2609 Anti-beta Arrestin 1 Antibody, clone 3H11.2

Anti-beta Arrestin 1 Antibody, clone 3H11.2 detects level of beta Arrestin 1 & has been published & validated for use in WB & IF.

Anti-beta Arrestin 1 Antibody, clone 3H11.2 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Cell Structure Research Sub-Category: Sensory & PNS, G-proteins Gene Symbol: ARRESTIN, S-AG, S-arrestin UniProt Number: P49407
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MAB2609
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IFMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB2609
      DescriptionAnti-beta Arrestin 1 Antibody, clone 3H11.2
      Alternate Names
      • Retinal S-antigen
      • Rod photoreceptor arrestin
      • S-antigen
      • retina and pineal gland (arrestin)
      • arrestin 1
      • retinal S-antigen (48 KDa protein)
      Background InformationThe Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta Arrestin 1), Arrestin 3 (beta Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, beta Arrestins 1 and 2 are ubiquitously expressed. Beta Arrestins appear to act as negative regulators on G protein-coupled receptors, (Lefkowitz, 1998). Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases, (Lin, 1998; Miller, 2001).
      References
      Product Information
      FormatPurified
      Control
      • HEK293 cell lysate
      PresentationPurified in PBS with 0.05% NaN3.
      Quality LevelMQ100
      Applications
      ApplicationAnti-beta Arrestin 1 Antibody, clone 3H11.2 detects level of beta Arrestin 1 & has been published & validated for use in WB & IF.
      Key Applications
      • Western Blotting
      • Immunofluorescence
      Biological Information
      ImmunogenKLH conjugated synthetic peptide corresponding to amino acids 357-372 of human beta arrestin 1.
      Epitopea.a. 357-372
      Cloneclone 3H11.2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityReacts with human beta-arrestin 1.
      IsotypeIgMκ
      Species Reactivity
      • Human
      Species Reactivity NoteReacts with human. Other species have not been tested.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryMembers of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. [provided by RefSeq]
      Gene Symbol
      • ARRESTIN
      • S-AG
      • S-arrestin
      UniProt Number
      UniProt SummaryFUNCTION: Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.
      SEQUENCE SIMILARITIES: Belongs to the arrestin family.
      Molecular Weight~47 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated on a representative lot by Western blot in HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MAB2609 04053252358982

      Documentation

      Anti-beta Arrestin 1 Antibody, clone 3H11.2 FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-beta Arrestin 1 Antibody, clone 3H11.2 Certificats d'analyse

      TitreNuméro de lot
      Anti-beta Arrestin 1, clone 3H11.2 Monoclonal Antibody - 2120062 2120062
      Anti-beta Arrestin 1, clone 3H11.2 Monoclonal Antibody - 2390578 2390578
      Anti-beta Arrestin 1, clone 3H11.2 - 2433495 2433495
      Anti-beta Arrestin 1, clone 3H11.2 - 2246812 2246812
      Anti-beta Arrestin 1, clone 3H11.2 - 3123692 3123692
      Anti-beta Arrestin 1, clone 3H11.2 - 3688992 3688992
      Anti-beta Arrestin 1, clone 3H11.2 - 3800097 3800097
      Anti-beta Arrestin 1, clone 3H11.2 - 3852796 3852796
      Anti-beta Arrestin 1, clone 3H11.2 - JBC1793819 JBC1793819
      Anti-beta Arrestin 1, clone 3H11.2 - NG1604143 NG1604143
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