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05-944 Anti-Ubiquitin Antibody, clone P4D1-A11

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05-944
100 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Vrt, Yeast (S. cerevisiae)WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-944
      Replaces04-454
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Ubiquitin Antibody, clone P4D1-A11
      Product Information
      FormatPurified
      Presentation100 μg of protein G purified mouse IgG in 100 μL of 70% storage buffer (0.014M phosphate buffer, pH 7.6, 0.175M NaCl, 0.07% sodium azide) and 30% glycerol.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Ubiquitin Antibody, clone P4D1-A11 is an antibody against Ubiquitin for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogentotal bovine ubiquitin
      CloneP4D1-A11
      HostMouse
      SpecificityUbiquitin, Mr = 8 kDa, and several ubiquitinated proteins
      IsotypeIgG
      Species Reactivity
      • Human
      • Vertebrates
      • Yeast (S. cerevisiae)
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.
      Gene Symbol
      • RPS27A
      • CEP80
      • ubiquitin
      • ubiquitin-CEP80
      • UBCEP1
      • Ubiquitin.
      • UBA52
      • UBCEP2
      • UBA80
      • UBC
      • UBB
      • HUBCEP80
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P62988 # Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair.
      SIZE: 76 amino acids; 8565 Da
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
      PTM: Several types of polymeric chains can be formed, depending on the lysine used for the assembly.
      SIMILARITY: SwissProt: P62988 ## Belongs to the ubiquitin family.
      MISCELLANEOUS: Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a).
      Molecular Weight8 kDa and higher
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot of human recombinant ubiquitin (Catalog # 12-558), and ubiquitinated proteins in acid extracts from HeLa cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Référence GTIN
      05-944 04053252275715