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MABE1820-25UL Anti-Neurofibromin C Antibody, clone NFC

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MABE1820-25UL
25 µL  
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      Aperçu

      Replacement Information
      Description
      Catalogue NumberMABE1820-25UL
      DescriptionAnti-Neurofibromin C Antibody, clone NFC
      Alternate Names
      • Neurofibromatosis-related protein NF-1
      Background InformationNeurofibromin (UniProt: P21359; also known as Neurofibromatosis-related protein NF-1) is encoded by the NF1 gene (Gene ID: 4763) in human. Neurofibromin is a GTPase-activating protein that negatively regulates RAS/MAOK pathway by enhancing the hydrolysis of Ras-bound GTP. Hence, it can display tumor suppressor properties. Neurofibromin has been detected in brain, peripheral nerves, lung, colon, and muscle tissues. It has a CRAL-TRIO domain (aa 1580-1738) that facilitates its binding to phospholipids. It binds primarily glycerophospholipids with monounsaturated C18:1 and/or C16:1 fatty acid moieties and a phosphatidylethanolamine or phosphatidylcholine head group. Neurofibromin also has a Ras-GTP domain (aa 1235-1451). Mutations in NF1 gene are known to cause Neurofibromatosis type I that involved tumors in the peripheral nervous system and fibromatous skin tumors. Some mutations are also known to cause colorectal cancer and juvenile leukemia. Six different isoforms of Neurofibromin have been described that are produced by alternative splicing. (Ref.: Rossi, S., et al. (2018). Mod. Pathol. 31(1), 160-168).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Neurofibromin C, clone NFC, Cat. No. MABE1820, is a highly specific mouse monoclonal antibody that targets Neurofibromin and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry (Paraffin) Analysis: A representative lot detected Neurofibromin C in Immunohistochemistry applications (Rossi, S., et. al. (2018). Mod Pathol. 31(1):160-168).
      Western Blotting Analysis: A representative lot detected Neurofibromin C lysate from human NF1 +/+ cells, but not in -/- cells or NF1+/+ cells transfected with siRNA targeting neurofibromin (Reuss, DE.,et al., (2014). Acta Neuropathol. 127(4); 565-572).
      Biological Information
      ImmunogenRecombinant fragment corresponding to 281 amino acids from the C-terminal region of human Neurofibromin C.
      EpitopeC-terminus
      CloneNFC
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone NFC specifically detects human Neurofibromin C. it targets an epitope with in the C-terminal region.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • NF1
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight319.37 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in human kidney tissue sections.

      Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected Neurofibromin C in human kidney tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABE1820-25UL 04054839755224

      Documentation

      Anti-Neurofibromin C Antibody, clone NFC Certificats d'analyse

      TitreNuméro de lot
      Anti-Neurofibromin C, clone NFC - 3209563 3209563

      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      Targeting Multiple Tumors Using T-Cells Engineered to Express a Natural Cytotoxicity Receptor 2-Based Chimeric Receptor.
      Eisenberg, V; Shamalov, K; Meir, S; Hoogi, S; Sarkar, R; Pinker, S; Markel, G; Porgador, A; Cohen, CJ
      Front Immunol  8  1212  2016

      Afficher le résumé
      28862263 28862263