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MABN358 Anti-NB thymosin beta (TMSB15A Antibody), Clone 4A6.3

This Anti-NB thymosin beta (TMSB15A Antibody), Clone 4A6.3 is validated for use in Immunohistochemistry (Paraffin) for the detection of NB thymosin beta (TMSB15A).

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Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: TMSB15A, TMSL8, TMSNB UniProt Number: P0CG34
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MABN358
100 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN358
      DescriptionAnti-NB thymosin beta (TMSB15A Antibody), Clone 4A6.3
      Alternate Names
      • Thymosin beta-15A
      • NB thymosin beta
      • Thymosin-like protein 8
      Background InformationTMSB15A protein is a key regulator of the cytoskeleton organization and polymerization, and it thus plays a role in cell migration, proliferation and cancer. TMSB15A does this because TMSB15A binds to and sequesters actin monomers and limits action polymerization. TMSB15A is differentially expressed in many tissues and cancer cell lines. Because of differential expression in certain cancers, for instance in triple negative breast cancer but not colon cancer, TMSB15A is being examined as a histochemical marker for measuring the effectiveness of cancer therapy on cancer. TMSB15A is also important in the nervous system and brain diseases. Notably, TMSB15A expression is increased upon brain stress and surprisingly TMSB15A localization differs depending upon the type of stress used and neuronal cell type. Because of its interaction with actin, TMSB15A is localized to the cytoplasm most of time, however, in the brain and when cells are placed under various stresses, TMSB15A can be translocated to the brain to perform yet unknown functions as well.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-NB thymosin beta (TMSB15A Antibody), Clone 4A6.3 is validated for use in Immunohistochemistry (Paraffin) for the detection of NB thymosin beta (TMSB15A).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TMSB15A in human thalamic and human brain cancer tissues.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to Human TMSB15A.
      Clone4A6.3
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgMκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TMSB15A
      • TMSL8
      • TMSNB
      UniProt Number
      Molecular Weight5 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human cerebral cortex tissue.

      Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TMSB15A in human cerebral cortex tissue
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABN358 04055977073720