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MABT529 Anti-Integrin beta-1 (CD29) Antibody, clone 13C4.1

This mouse monoclonal Anti-Integrin beta-1 (CD29), clone 13C4.1, Cat. No. MABT529, is validated for use in Immunohistochemistry (Paraffin) and Western Blotting for the detection of Integrin beta-1.

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Research Category: Cell Structure Gene Symbol: ITGB1, FNRB, MDF2, MSK12, VLA-BETA, VLAB UniProt Number: P05556
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MABT529
100 µL  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT529
      Replaces04-1109
      DescriptionAnti-Integrin beta-1 (CD29) Antibody, clone 13C4.1
      Alternate Names
      • Integrin beta-1
      • CD29
      • Glycoprotein Iia
      • GPIIA
      • Integrin VLA-4 subunit beta
      • Very late activation protein
      • beta polypeptide
      Background InformationIntegrin beta-1 (UniProt P05556; also known as CD29, Glycoprotein Iia, GPIIA, Integrin VLA-4 subunit beta, Very late activation protein, beta polypeptide) is encoded by the ITGB1 (also known as FNRB, MDF2, MSK12, VLA-BETA, VLAB) gene (Gene ID 3688) in human. Integrin beta-1 is a 130 kDa transmembrane glycoprotein that interact with various integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptor complexes that bind to specific extracellular matrix proteins. Integrin receptors regulate a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor growth and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to the activation of signal transduction pathways and regulation of gene expression.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis mouse monoclonal Anti-Integrin beta-1 (CD29), clone 13C4.1, Cat. No. MABT529, is validated for use in Immunohistochemistry (Paraffin) and Western Blotting for the detection of Integrin beta-1.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Integrin beta-1 in human breast cancer, cerebral cortex, and lung tissue sections.
      Biological Information
      ImmunogenGST-tagged recombinant human Integrin beta-1 fragment corresponding to the membrane-proximal extracellular region.
      Clone13C4.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 13C4.1 targets an epitope within the membrane-proximal extracellular region present in all five spliced isoforms of human Integrin beta-1 reported by UniPort (P05556).
      IsotypeIgG1λ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ITGB1
      • FNRB
      • MDF2
      • MSK12
      • VLA-BETA
      • VLAB
      Purification MethodProtein G purified.
      UniProt Number
      Molecular Weight~150 kDa observed. Target band size appears larger than the calculated molecular weights of 88.42/87.45/91.62/91.03/88.88 kDa (isoform Beta-1A/Beta-1B/Beta-1C/Beta-1C-2/Beta-1D pro-form) and 86.19/85.22/89.40/88.81/86.66 kDa (mature isoform Beta-1A/Beta-1B/Beta-1C/Beta-1C-2/Beta-1D) due to glycosylation. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in U937 cell lysate.

      Western Blotting Analysis: A 1:2,000 dilution of this antibody detected Integrin beta-1 in 10 µg of U937 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABT529 04054839081408