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MAB1950Z Anti-Integrin α2 Antibody, clone P1E6, azide free

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MAB1950Z
100 µg  
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      Replacement Information

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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HICC, IHC, FUNCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB1950Z
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Integrin α2 Antibody, clone P1E6, azide free
      Alternate Names
      • CD49b
      • MAB1950
      References
      Product Information
      FormatPurified
      Control
      • Skin (Basement membrane)
      PresentationProtein A Purified mouse immunoglobulin in 0.01 M phosphate buffered saline, pH 7.1, with no preservatives.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Integrin α2 Antibody, clone P1E6, azide free is validated for use in IC, IH, FUNC for the detection of Integrin α2.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Affects Function
      Applications Not Recommended
      • Immunohistochemistry (Paraffin)
      Application NotesSuitable for use in attachment inhibition assays using fibroblasts, epithelial cells, endothelial cells, and non-activated platelets on collagen types I, III, IV, VI and laminin.

      Suitable for immunofluorescence using fresh frozen or acetone fixed tissues. Not recommended for traditional formalin fixed paraffin embedded tissues.

      Final working dilutions must be determined by end user.
      Biological Information
      CloneP1E6
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityRecognizes Alpha 2 integrin.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.
      Gene Symbol
      • ITGA2
      • CD49B
      • VLAA2
      • VLA-2
      • CD49b
      • BR
      • GPIa
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17301 # Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
      SIZE: 1181 amino acids; 129295 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DOMAIN: SwissProt: P17301 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
      SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MAB1950Z 04053252360084

      Documentation

      Anti-Integrin α2 Antibody, clone P1E6, azide free FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-Integrin α2 Antibody, clone P1E6, azide free Certificats d'analyse

      TitreNuméro de lot
      MOUSE ANTI-HUMAN INTEGRIN alpha 2 PRESERVATIVE FREE MONOCLONAL ANTIBODY - 2428537 2428537
      MOUSE ANTI-HUMAN INTEGRIN alpha 2 - 3219925 3219925
      MOUSE ANTI-HUMAN INTEGRIN alpha 2 - 3496871 3496871
      MOUSE ANTI-HUMAN INTEGRIN alpha 2 - 3855741 3855741
      MOUSE ANTI-HUMAN INTEGRIN alpha 2 - 4090685 4090685
      MOUSE ANTI-HUMAN INTEGRIN alpha 2 -2557544 2557544
      MOUSE ANTI-HUMAN INTEGRIN alpha 2 -2576357 2576357
      MOUSE ANTI-HUMAN INTEGRIN alpha 2 -2631540 2631540
      MOUSE ANTI-HUMAN INTEGRIN alpha 2 -2659248 2659248
      MOUSE ANTI-HUMAN INTEGRIN alpha 2 -2685216 2685216

      Références bibliographiques

      Aperçu de la référence bibliographiqueApplicationNº PubMed
      Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity.
      Yao, Y; Chen, ZL; Norris, EH; Strickland, S
      Nature communications  5  3413  2014

      Afficher le résumé
      Immunohistochemistry24583950 24583950
      Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces.
      Mierke, CT; Frey, B; Fellner, M; Herrmann, M; Fabry, B
      Journal of cell science  124  369-83  2010

      Afficher le résumé
      21224397 21224397
      Design and activity of multifunctional fibrils using receptor-specific small peptides.
      Y Ohga, F Katagiri, K Takeyama, K Hozumi, Y Kikkawa, N Nishi, M Nomizu
      Biomaterials  30  6731-8  2009

      Afficher le résumé
      19765823 19765823
      Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices.
      Stratman, AN; Saunders, WB; Sacharidou, A; Koh, W; Fisher, KE; Zawieja, DC; Davis, MJ; Davis, GE
      Blood  114  237-47  2009

      Afficher le résumé Article en texte intégral
      19339693 19339693
      Regulation of human beta-cell adhesion, motility, and insulin secretion by collagen IV and its receptor alpha1beta1.
      Kaido, T; Yebra, M; Cirulli, V; Montgomery, AM
      The Journal of biological chemistry  279  53762-9  2004

      Afficher le résumé
      15485856 15485856
      Induction of endothelial cell activation by a triple helical alpha2beta integrin ligand, derived from type I collagen alpha1(I)496-507.
      Baronas-Lowell, D; Lauer-Fields, JL; Fields, GB
      The Journal of biological chemistry  279  952-62  2004

      Afficher le résumé
      14581484 14581484
      Engineering integrin-specific surfaces with a triple-helical collagen-mimetic peptide.
      Catherine D Reyes, Andrés J García, Catherine D Reyes, Andrés J García
      Journal of biomedical materials research. Part A  65  511-23  2003

      Afficher le résumé
      12761842 12761842
      Association between alphavbeta6 integrin expression, elevated p42/44 kDa MAPK, and plasminogen-dependent matrix degradation in ovarian cancer.
      Ahmed, Nuzhat, et al.
      J. Cell. Biochem., 84: 675-86 (2002)  2002

      Afficher le résumé
      11835393 11835393
      A peptide model of basement membrane collagen alpha 1 (IV) 531-543 binds the alpha 3 beta 1 integrin.
      Miles, A J, et al.
      J. Biol. Chem., 270: 29047-50 (1995)  1994

      Afficher le résumé
      7493922 7493922
      Co-clustering of beta 1 integrins, cytoskeletal proteins, and tyrosine-phosphorylated substrates during integrin-mediated leukocyte aggregation.
      Sánchez-Mateos, P, et al.
      J. Immunol., 151: 3817-28 (1993)  1992

      Afficher le résumé
      7690816 7690816

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      Alternative Format

      Référence Description  
      MAB1950 Anti-Integrin α2 Antibody, clone P1E6 Prix & Disponibilité

      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies