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MABS490 Anti-Hexosaminidase subunit A Antibody, clone 13D12.1

Anti-Hexosaminidase subunit A Antibody, clone 13D12.1 is an antibody against Hexosaminidase subunit A for use in Western Blotting, Immunohistochemistry (Paraffin).

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Research Category: Signaling Research Sub-Category: Developmental Signaling Gene Symbol: HEXA UniProt Number: P06865
MABS490
100 μg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS490
      DescriptionAnti-Hexosaminidase subunit A Antibody, clone 13D12.1
      Alternate Names
      • Beta-hexosaminidase subunit alpha
      • Hexosaminidase subunit A
      • Beta-N-acetylhexosaminidase subunit alpha
      • N-acetyl-beta-glucosaminidase subunit alpha
      Background InformationBeta-hexosaminidase subunit alpha (EC 3.2.1.52; UniProt P06865; also known as Beta-N-acetylhexosaminidase subunit alpha, Hexosaminidase subunit A, N-acetyl-beta-glucosaminidase subunit alpha) is encoded by the HEXA (also known as TSD) gene (Gene ID 3073) in human. The enzyme β-hexosaminidase is composed of two polypeptide chains designated the α- and β- subunits. β-hexosaminidase interacts with its co-factor GM2 activator protein and catalyzes the degradation of the GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines. Mutations in any of the three genes coding for the two enzyme subunits and the co-factor protein are known causes of neurodegenerative autosomal recessive lysosomal storage diseases collectively known as GM2 gangliosidoses. Tay-Sachs disease (TSD) is linked to HEXA mutations, Sandhoff disease is linked to HEXB mutations, and AB-variant form is linked to GM2A mutations.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Hexosaminidase subunit A Antibody, clone 13D12.1 is an antibody against Hexosaminidase subunit A for use in Western Blotting, Immunohistochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected Hexosaminidase subunit A in 10 µg of human placenta tissue lysate.
      Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected Hexosaminidase subunit A in human cerebral cortex and human small intestine tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the internal (C-terminal half) of human Hexosaminidase subunit A.
      EpitopeInternal (C-terminal half)
      Clone13D12.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityReactivity toward spliced isoform 2 has not been determined.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HEXA
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~60 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HepG2 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Hexosaminidase subunit A in 10 µg of HepG2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABS490 04055977297409