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MAB10234-I-100UG Anti-Hepatitis B Virus Surface Antigen Antibody, clone H21F8-1

Anti-Hepatitis B Virus Surface Antigen, clone H21F8-1, Cat. No. MAB10234-I, is a mouse monoclonal antibody that detects Large envelope protein of Hepatitis B virus and is tested for use in Immunohistochemistry (Paraffin).

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MAB10234-I-100UG
100 μg  
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      Replacement Information
      Description
      Catalogue NumberMAB10234-I-100UG
      DescriptionAnti-Hepatitis B Virus Surface Antigen Antibody, clone H21F8-1
      Alternate Names
      • Large envelope protein
      • L glycoprotein
      • L-HBsAg
      • LHB
      • Large S
      Background InformationLarge envelope protein (UniProt: A7XR30; also known as L glycoprotein, L-HBsAg, LHB, Large S protein, Large surface protein, Major surface antigen) is encoded by the S (also known as Large S, P, preS1, preS2) gene (Gene ID: 944569) in Hepatitis B virus (HBV). HBV is a small enveloped virus of the Hepadnaviridae family with a partially double-stranded DNA genome approximately 3.2 kb. Hepatitis B surface antigen is a distinctive serological marker of acute or chronic hepatitis B infection and is the first antigen to appear following infection with hepatitis B virus. HBV contains three viral envelope/surface proteins - large surface antigen, middle surface antigen, and small surface antigen. They are expressed from a single open reading frame. The large envelope protein is synthesized with the pre-S region at the cytosolic side of the endoplasmic reticulum and is not N-glycosylated. It is shown to exist in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein. (Ref.: Wu, CC., et al. (2018). World J. Gastroenterol. 24(31);: 3488 3499).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgM in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ200
      Applications
      ApplicationAnti-Hepatitis B Virus Surface Antigen, clone H21F8-1, Cat. No. MAB10234-I, is a mouse monoclonal antibody that detects Large envelope protein of Hepatitis B virus and is tested for use in Immunohistochemistry (Paraffin).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenHepatitis B virus surface antigen (HBsAg).
      EpitopeUnknown
      CloneH21F8-1
      Concentration1.0 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone H21F8-1 is a mouse monoclonal antibody that detects large envelope protein of Hepatitis B virus.
      IsotypeIgM
      Species Reactivity
      • Virus
      Species Reactivity NoteHepatitis B Virus.
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • S
      Purification MethodLigatrap
      UniProt Number
      Molecular Weight43.72 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in Hepatitis B virus infected liver (HBsAg-positive) tissue sections.

      Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected Hepatitis B Virus Surface Antigen in Hepatitis B virus infected liver (HBsAg-positive) tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommend storage at +2°C to +8°C. For long term storage antibodies can be kept at -20°C. Avoid repeated freeze-thaws.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MAB10234-I-100UG 04065266876222