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AB763P Anti-Collagen Type V Antibody

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AB763P
100 µg  
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      Replacement Information

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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, IF, RIARbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB763P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Collagen Type V Antibody
      OverviewCollagen Type V extracted and purified from human placenta. Antibody shows less than 0.1% reactivity with human Collagen Types I, III, and IV. AB763P also shows 0.1% reactivity with human Fibronectin and mouse Laminin by radioimmunoassay.
      References
      Product Information
      FormatPurified
      PresentationThe purified antibody is supplied in a buffer containing a mixture of 0.1M Citrate, 0.1M potassium phosphate, at a pH of 7.2-7.4 and 10µl/ml of antibiotics and antimycotics
      Quality LevelMQ100
      Applications
      ApplicationAnti-Collagen Type V Antibody detects level of Collagen Type V & has been published & validated for use in ELISA, IF, RIA.
      Key Applications
      • ELISA
      • Immunofluorescence
      • Radioimmunoassay
      Application NotesImmunohistochemistry: 1:40 dilution for immunofluorescent staining of frozen human skin, liver and placenta tissues.

      Radio Immunoassay

      ELISA

      Optimal working dilution must be determined by end user.
      Biological Information
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityHuman collagen type V: 100%

      Human collagen type I, II, & III: < 0.5%

      Human collagen type IV: 20%

      Human fibronectin, albumin, immunoglobulins: < 0.5%.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II.
      Gene Symbol
      • COL5A1
      • OTTHUMP00000064637
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P20908 # Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
      SIZE: 1838 amino acids; 183560 Da
      SUBUNIT: Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4.
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
      PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. & Sulfated on 40% of tyrosines.
      DISEASE: SwissProt: P20908 # Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type I (EDS-I) [MIM:130000]; also known as Ehlers-Danlos syndrome gravis. EDS-I is a connective-tissue disorder characterized by loose-jointedness and fragile, velvety, stretchable, bruisable skin that heals with peculiar 'cigarette-paper' scars. Inheritance is autosomal dominant. & Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type II (EDS-II) [MIM:130010]; also known as Ehlers-Danlos syndrome mitis. Inheritance is autosomal dominant.
      SIMILARITY: SwissProt: P20908 ## Belongs to the fibrillar collagen family. & Contains 1 laminin G-like domain. & Contains 1 TSP N-terminal (TSPN) domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      AB763P 04053252730856

      Documentation

      Anti-Collagen Type V Antibody FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-Collagen Type V Antibody Certificats d'analyse

      TitreNuméro de lot
      Anti-Human Collagen Type V - 4157262 4157262
      RABBIT ANTI- HUMAN COLLAGEN TYPE V 2478861
      RABBIT ANTI- HUMAN COLLAGEN TYPE V POLYCLONAL ANTIBODY - 2145915 2145915
      RABBIT ANTI- HUMAN COLLAGEN TYPE V POLYCLONAL ANTIBODY - 2426497 2426497
      RABBIT ANTI- HUMAN COLLAGEN TYPE V - 3224610 3224610
      RABBIT ANTI- HUMAN COLLAGEN TYPE V - 3474956 3474956
      RABBIT ANTI- HUMAN COLLAGEN TYPE V - 3748880 3748880
      RABBIT ANTI- HUMAN COLLAGEN TYPE V -2578189 2578189
      RABBIT ANTI- HUMAN COLLAGEN TYPE V -2607065 2607065
      RABBIT ANTI- HUMAN COLLAGEN TYPE V -2736654 2736654

      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      Colorectal cancer desmoplastic reaction up-regulates collagen synthesis and restricts cancer cell invasion.
      Vivien J Coulson-Thomas,Yvette M Coulson-Thomas,Tarsis F Gesteira,Cláudia A A de Paula,Ana M Mader,Jaques Waisberg,Maria A Pinhal,Andreas Friedl,Leny Toma,Helena B Nader
      Cell and tissue research  346  2010

      Afficher le résumé
      21987222 21987222