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05-826-AF488 Anti-Bcl-2 Antibody, clone AW604, Alexa Fluor® 488 Conjugate

This Anti-Bcl-2 Antibody, clone AW604, Alexa Fluor® 488 Conjugate is validated for use in Immunocytochemistry, Flow Cytometry for the detection of Bcl-2.

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Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: BCL2 UniProt Number: P10415
05-826-AF488
100 µL  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HICC, FCMAlexaFluor®488Monoclonal Antibody
      Description
      Catalogue Number05-826-AF488
      DescriptionAnti-Bcl-2 Antibody, clone AW604, Alexa Fluor® 488 Conjugate
      Alternate Names
      • Apoptosis regulator Bcl-2
      • Bcl-2
      Background InformationApoptosis regulator Bcl-2 (UniProt P10415) is encoded by the BCL2 gene (Gene ID 596) in human. Bcl-2 is an anti-apoptotic and the founding member of the Bcl-2 family of proteins that play either a pro- or anti-apoptotic role in cell death signaling. Bcl-2 family members are related by regions of sequence and structural homology. The pro-survival members contain four Bcl-2 homology regions (BH1–BH4), whereas the BH3-only members contain only the BH3 amphipathic helix, which mediates their interaction with the groove of multi-domain BCL-2 family members. Human BCL2 gene mutations are well known causes of many cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer.
      References
      Product Information
      FormatAlexaFluor®488
      PresentationPurified mouse monoclonal IgG2a antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Bcl-2 Antibody, clone AW604, Alexa Fluor® 488 Conjugate is validated for use in Immunocytochemistry, Flow Cytometry for the detection of Bcl-2.
      Key Applications
      • Immunocytochemistry
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 1.0 µg of this antibody from a representative lot detected Bcl-2 in 1X10E6 Raji cells.
      The unconjugated antibody (Cat. No. 05-826) is shown to be suitable also for Western blotting and immunoprecipitation applications.
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide corresponding to amino acids 41-54 (C-GAAPAPGIFSSQPG) of human Bcl-2.
      Epitope Amino acids 41-54.
      CloneAW604
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityExpected to react with both Alpha and Beta spliced isoforms reported by UniProt (P10415-1 and P10415-2, respectively).
      IsotypeIgG2a
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • BCL2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~26 kDa observed.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in Jurkat cells.

      Immunocytochemistry Analysis: A 1:50 dilution of this antibody detected Bcl-2 in Jurkat cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      05-826-AF488 04055977314724

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      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies