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07-208 Anti-AIF (Apoptosis Inducing Factor) Antibody

Anti-AIF (Apoptosis Inducing Factor) Antibody detects level of AIF (Apoptosis Inducing Factor) & has been published & validated for use in WB.

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Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: AIFM1, MGC111425, PDCD8, AIF UniProt Number: O95831
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07-208
200 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-208
      Replaces04-430
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-AIF (Apoptosis Inducing Factor) Antibody
      References
      Product Information
      FormatPurified
      HS Code3002 15 90
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Quality LevelMQ100
      Applications
      ApplicationAnti-AIF (Apoptosis Inducing Factor) Antibody detects level of AIF (Apoptosis Inducing Factor) & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpeptide corresponding to amino acids 593-606 of human Apoptosis Inducing Factor, AIF (C-KDGEQHEDLNEVAK), containing a N-terminal cysteine
      HostRabbit
      SpecificityAIF
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Three alternative transcripts encoding different isoforms have been identified for this gene.
      Gene Symbol
      • AIFM1
      • MGC111425
      • PDCD8
      • AIF
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O95831 # Probable oxidoreductase that acts as a caspase- independent mitochondrial effector of apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large scale DNA fragmentation (in vitro).
      COFACTOR: FAD.
      SIZE: 613 amino acids; 66901 Da
      SUBUNIT: Binds to DNA in a sequence-independent manner.
      SUBCELLULAR LOCATION: Mitochondrion intermembrane space. Nucleus. Note=Translocated to the nucleus upon induction of apoptosis.
      SIMILARITY: SwissProt: O95831 ## Belongs to the FAD-dependent oxidoreductase family.
      Molecular Weight57kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on a mouse liver preparation
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      07-208 04053252336416

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      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies