Millipore Sigma Vibrant Logo

172060 Andrographolide - CAS 5508-58-7 - Calbiochem

A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties.

Andrographolide - CAS 5508-58-7 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Andro

Primary Target: NF-κB and AP-1 activation
View Products on Sigmaaldrich.com
172060
Voir les Prix & la Disponibilité

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
5508-58-7C₂₀H₃₀O₅

Prix & Disponibilité

Référence DisponibilitéConditionnement Qté Prix Quantité
172060-50MG
Récupération des données relatives à la disponibilité...
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

      		 Ampoule plast. 50 mg
      Prix en cours de récupération
      Le prix n'a pas pu être récupéré
      La quantité minimale doit être un multiple de
      Maximum Quantity is
      À la validation de la commande Plus d'informations
      Vous avez sauvegardé ()
       
      —
      Demander le prix
      		 —
      Description
      OverviewA bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Acts as an irreversible antagonist of NF-κB and AP-1 (IC50 ≤ 15 µM) activation, and prevents in vitro and in vivo T cell activation. Exerts no effect on IκBα degradation, p50 and p65 nuclear translocation. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in mouse model. Further, reported to activate PI 3K/Akt pathway.
      Catalogue Number172060
      Brand Family Calbiochem®
      SynonymsAndro
      References
      ReferencesXia, Y.F., et al. 2004. J. Immunol. 173, 4207.
      Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337.
      Yu, B.C., et al. 2003. Planta Med. 69, 1075.
      Product Information
      CAS number5508-58-7
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₀H₃₀O₅
      Chemical formulaC₂₀H₃₀O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNF-κB and AP-1 activation
      Primary Target IC<sub>50</sub>≤ 15 µM against NF-κB and AP-1 activation
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSLU3490750
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      172060-50MG 04055977222883

      Documentation

      Andrographolide - CAS 5508-58-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Andrographolide - CAS 5508-58-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      172060

      Références bibliographiques

      Aperçu de la référence bibliographique
      Xia, Y.F., et al. 2004. J. Immunol. 173, 4207.
      Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337.
      Yu, B.C., et al. 2003. Planta Med. 69, 1075.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-April-2008 RFH
      SynonymsAndro
      DescriptionAn irreversible blocker of NF-κB and AP-1 (IC50 ≤ 15 µM) activation that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Exerts no effect on IκBα degradation of nuclear translocation p50 and p65. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in a mouse model. Reported to supress Cytochrome C release and apoptosis by activating the PI 3-K/Akt pathway.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number5508-58-7
      RTECSLU3490750
      Chemical formulaC₂₀H₃₀O₅
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityDMSO (15 mg/ml) or Chloroform:Methanol (1:1) (10 mg/ml). Use only fresh DMSO.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 633
      ReferencesXia, Y.F., et al. 2004. J. Immunol. 173, 4207.
      Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337.
      Yu, B.C., et al. 2003. Planta Med. 69, 1075.