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171262 AMPK Activator V, Ampkinone - CAS 1233082-79-5 - Calbiochem

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Tableau de caractéristiques principal

CAS #Empirical Formula
1233082-79-5C₃₁H₂₃NO₆

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171262-5MG
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      Description
      OverviewA cell-permeable benzopyran compound that stimulates both LKB1 and CaMKK-mediated AMPK activity indirectly with no noticeable effect on purified AMPK, cellular AMP/ATP ratio, PI 3-K/Akt signaling and respiratory chain, and displays antidiabetic and antiobesity properties. Shown to induce phosphorylation of AMPK-Thr172 and ACC-Ser79 in L6 cells (EC50 = 4.3 µM), C2C12 myocytes, 3T3-L1 preadipocytes and HepG2 hepatic cells, and enhance glucose uptake and insulin sensitivity in high fat-diet-induced obesity mouse model (10 mg/kg, s.c.) with the lowering of cholesterol and nonesterified fatty acids.
      Catalogue Number171262
      Brand Family Calbiochem®
      SynonymsAKN, AMPK Signaling Activator V
      References
      ReferencesOh, S., et al. 2010. J. Med. Chem. 53, 7405.
      Product Information
      CAS number1233082-79-5
      FormYellow powder
      Hill FormulaC₃₁H₂₃NO₆
      Chemical formulaC₃₁H₂₃NO₆
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      171262-5MG 04055977207187