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565781 β-Secretase Substrate VI, Fluorogenic - Calbiochem

A highly selective, fluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE); (pH ~4.0, kcat = 0.02 sec⁻¹; Km = 9 µM).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: H-K(DABSYL)-SEVNLDAEFRQ(LY)

565781
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565781-500UG
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      		 Ampoule plast. 500 μg
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      Description
      OverviewA highly selective, fluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE); (pH ~4.0, kcat = 0.02 sec-1; Km = 9 µM). Derived from the Swedish mutant APP (amyloid precursor protein) β-cleavage site (-NL↓DA-). Useful for high throughput screening of β-secretase inhibitors.
      Catalogue Number565781
      Brand Family Calbiochem®
      SynonymsH-K(DABSYL)-SEVNLDAEFRQ(LY)
      References
      ReferencesGrüninger-Leitch, F., et al. 2002. J. Biol. Chem. 277, 4687.
      Product Information
      ATP CompetitiveN
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₈₉H₁₂₂N₂₄O₃₁S₃
      Chemical formulaC₈₉H₁₂₂N₂₄O₃₁S₃
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE)
      Primary Target IC<sub>50</sub>kcat = 0.02 sec⁻¹ and Km = 9 µM at pH ~4.0 as fluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequenceH-Lys(DABSYL)-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Gin-(LY)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      565781-500UG 04055977267297

      Documentation

      β-Secretase Substrate VI, Fluorogenic - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      565781

      Références bibliographiques

      Aperçu de la référence bibliographique
      Grüninger-Leitch, F., et al. 2002. J. Biol. Chem. 277, 4687.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2008 RFH
      SynonymsH-K(DABSYL)-SEVNLDAEFRQ(LY)
      DescriptionA highly selective, fluorescence resonance energy transfer (FRET) peptide substrate for b-secretase (BACE) (pH ~4.0, kcat = 0.02 sec-1; Km = 9 µM). Derived from the Swedish mutant APP (amyloid precursor protein) β-cleavage site (-NL ↓ DA-). Useful for high throughput screening of β-secretase inhibitors. Excitation max.: ~430 nm; emission max.: ~520 nm.
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₈₉H₁₂₂N₂₄O₃₁S₃
      Peptide SequenceH-Lys(DABSYL)-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Gin-(LY)
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesGrüninger-Leitch, F., et al. 2002. J. Biol. Chem. 277, 4687.