219330 Sigma-Aldrichβ-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem
The β-Catenin/Tcf Inhibitor, FH535, also referenced under CAS 108409-83-2, controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Cell Signaling applications.
More>> The β-Catenin/Tcf Inhibitor, FH535, also referenced under CAS 108409-83-2, controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Cell Signaling applications. Less<<Synonymes: Wnt Pathway Inhibitor IX, N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide
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Aperçu
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Tableau de caractéristiques principal
CAS # | Empirical Formula |
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108409-83-2 | C₁₃H₁₀Cl₂N₂O₄S |
Prix & Disponibilité
Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
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219330-10MG |
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Ampoule plast. | 10 mg |
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Description | |
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Overview | A cell-permeable sulfonamide compound that acts as a dual pathway inhibitor against Wnt/β-catenin (≥80% inhibition at 15 µM in β-catenin/Tcf-dependent cellular reporter assays) and PPARγ/δ (≥30% inhibition at 0.5 µM in PPRE cellular reporter assays) signalings. Although both FH535 and the structurally similar PPARγ-selective inhibitor GW9662 (Cat. No. 370700) inhibit coactivator/PPAR binding, only FH535 blocks β-catenin/PPARγ interaction and the antagonistic activity of FH535 does not involve the covalent modification of or non-covalent interaction with the PPAR ligand-binding site cystein residue that is crucial for GW9662 action. |
Catalogue Number | 219330 |
Brand Family | Calbiochem® |
Synonyms | Wnt Pathway Inhibitor IX, N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide |
References | |
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References | Handeli, S., and Simon, J.A. 2008. Mol. Cancer Ther. 7, 521. |
Product Information | |
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CAS number | 108409-83-2 |
Form | Yellow solid |
Hill Formula | C₁₃H₁₀Cl₂N₂O₄S |
Chemical formula | C₁₃H₁₀Cl₂N₂O₄S |
Structure formula Image | |
Quality Level | MQ100 |
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Purity | ≥99% by HPLC |
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Packaged under inert gas | Packaged under inert gas |
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Référence | GTIN |
219330-10MG | 04055977202090 |
Documentation
β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem FDS
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β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem Certificats d'analyse
Titre | Numéro de lot |
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219330 |
Références bibliographiques
Aperçu de la référence bibliographique |
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Handeli, S., and Simon, J.A. 2008. Mol. Cancer Ther. 7, 521. |