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14-253M p38β2/SAPK2b2 Protein, active, 250 µg

Active, N-terminal GST fusion protein corresponding to full length human p38β2/SAPK2b2 activated with MKK6. For use in Kinase Assays.

p38β2/SAPK2b2 Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-253M
250 µg  Also available in 10 μg size (cat#14-253) and in bulk (cat# 14-253-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-253M
      Brand Family Upstate
      Trade Name
      • Upstate
      Descriptionp38β2/SAPK2b2 Protein, active, 250 µg
      OverviewN-terminal GST fusion protein corresponding to full length human p38β2/SAPK2b2 activated with MKK6.
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal GST fusion protein corresponding to full length human p38β2/SAPK2b2 activated with MKK6. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourcefull length human p38β2/SAPK2b2, expressed in E. coli.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
      Gene Symbol
      • MAPK11
      • p38-2
      • SAPK2B
      • SAPK2
      • PRKM11
      • P38BETA2
      • P38B
      • p38b
      • p38Beta
      • p38beta2
      Protein Targetp38β2/SAPK2b2
      Purification MethodAffinity chromatography on glutathione-agarose beads
      Target Sub-FamilyCMGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q15759 # Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2.
      COFACTOR: Magnesium (By similarity).
      SIZE: 364 amino acids; 41357 Da
      TISSUE SPECIFICITY: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
      DOMAIN:SwissProt: Q15759 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
      PTM: Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme (Probable).
      SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.
      Molecular Weight71kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of myelin basic protein
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -20°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-253) and in bulk (cat# 14-253-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-253M 04053252283987