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681673 Wnt Antagonist III, Box5 - Calbiochem

Wnt Antagonist III, Box5, is a Wnt-5a-derived hexapeptide that antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration and invasion.

Wnt Antagonist III, Box5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Wnt-5a Antagonist, Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist

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681673
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₀H₅₀N₆O₁₃S₂

Pricing & Availability

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681673-10MG
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      		 Glass bottle 10 mg
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      Description
      OverviewA Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.
      Catalogue Number681673
      Brand Family Calbiochem®
      SynonymsWnt-5a Antagonist, Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist
      References
      ReferencesJenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473.
      Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.
      Product Information
      FormWhite lyophilized solid
      Hill FormulaC₃₀H₅₀N₆O₁₃S₂
      Chemical formulaC₃₀H₅₀N₆O₁₃S₂
      Quality LevelMQ100
      Applications
      ApplicationWnt Antagonist III, Box5, is a Wnt-5a-derived hexapeptide that antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration and invasion.
      Biological Information
      Purity≥90% by HPLC
      Physicochemical Information
      Peptide Sequencet-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      681673-10MG 04055977225211

      Documentation

      Wnt Antagonist III, Box5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Wnt Antagonist III, Box5 - Calbiochem Certificates of Analysis

      TitleLot Number
      681673

      References

      Reference overview
      Jenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473.
      Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-December-2010 RFH
      SynonymsWnt-5a Antagonist, Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist
      DescriptionA Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.
      FormWhite lyophilized solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₀H₅₀N₆O₁₃S₂
      Peptide Sequencet-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H
      Purity≥90% by HPLC
      SolubilityDMSO (50 mg/ml) or H₂O (4 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473.
      Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.