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662125 Ubiquitin Isopeptidase Inhibitor I, G5 - CAS 108477-18-5 - Calbiochem

The Ubiquitin Isopeptidase Inhibitor I, G5, also referenced under CAS 108477-18-5, controls the biological activity of Ubiquitin Isopeptidase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide, tetrahydro-4H-thiopyran-4-one, NSC-144303

Primary Target: Ubiquitin isopeptidase activity
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662125
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
108477-18-5C₁₉H₁₄N₂O₇S

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      Description
      OverviewA cell-permeable cross-conjugated α,β-unsaturated dienone compound that induces caspase activation and apoptosis (IC50 = 1.76 and 1.6 µM in E1A and E1A/C9DN cells, respectively) via the apoptosome-independent mitochondrial pathway by selectively inhibiting ubiquitin isopeptidase activity (IC50 = ~ 30 µM). The cellular expression of Bax and Bak is essential for G5-activated apoptosis, while Bcl-2 appears to protect cells against the effect of G5. G5 is more potent than, but otherwise exhibits similar pharmacological effects as, Ubiquitin Isopeptidase Inhibitor II, F6 (Cat. No. 662126). At higher concentrations (5-10 µM), shown to induce necrosis in apoptosis-resistant MEFs-DKO.
      Catalogue Number662125
      Brand Family Calbiochem®
      Synonyms3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide, tetrahydro-4H-thiopyran-4-one, NSC-144303
      References
      ReferencesFontanini, A., et al. 2009. J. Biol. Chem. 284, 8369.
      Aleo, E., et al. 2006. Cancer Res. 66, 9235.
      Product Information
      CAS number108477-18-5
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₉H₁₄N₂O₇S
      Chemical formulaC₁₉H₁₄N₂O₇S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetUbiquitin isopeptidase activity
      Primary Target IC<sub>50</sub>~ 30 µM against ubiquitin isopeptidase activity; 1.76 and 1.6 µM for the induction of caspase activation and apoptosis in E1A and E1A/C9DN cells, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsUnstable in DMSO; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      662125-10MG 04055977261226

      Documentation

      Ubiquitin Isopeptidase Inhibitor I, G5 - CAS 108477-18-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Ubiquitin Isopeptidase Inhibitor I, G5 - CAS 108477-18-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      662125

      References

      Reference overview
      Fontanini, A., et al. 2009. J. Biol. Chem. 284, 8369.
      Aleo, E., et al. 2006. Cancer Res. 66, 9235.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-November-2023 JSW
      Synonyms3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide, tetrahydro-4H-thiopyran-4-one, NSC-144303
      DescriptionA cell-permeable cross-conjugated α,β-unsaturated dienone compound that induces caspase activation and apoptosis (IC50 = 1.76 and 1.6 µM in E1A and E1A/C9DN cells, respectively) via the apoptosome-independent mitochondrial pathway by selectively inhibiting ubiquitin isopeptidase activity (IC50 ~30 µM). The cellular expression of Bax and Bak is essential for G5-activated apoptosis, while Bcl-2 appears to protect cells against the effect of G5. G5 is more potent than, but otherwise exhibits similar pharmacological effects as, Ubiquitin Isopeptidase Inhibitor II, F6 (Cat. No. 662126). At higher concentrations (5-10 µM), shown to induce necrosis in apoptosis-resistant MEFs-DKO.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number108477-18-5
      Chemical formulaC₁₉H₁₄N₂O₇S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in DMSO; reconstitute just prior to use.
      Toxicity Irritant
      ReferencesFontanini, A., et al. 2009. J. Biol. Chem. 284, 8369.
      Aleo, E., et al. 2006. Cancer Res. 66, 9235.