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572650 SU9516 - CAS 666837-93-0 - Calbiochem

A cell-permeable 3-substituted indolinone compound that displays anti-proliferative and proapoptotic properties in tumor cells.

SU9516 - CAS 666837-93-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one

Primary Target: Cdk2/A
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572650
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
666837-93-0C₁₃H₁₁N₃O₂

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      Description
      OverviewA cell-permeable 3-substituted indolinone compound that displays anti-proliferative and proapoptotic properties in tumor cells. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks; IC50 = 22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1). It shows no significant effect (IC50 >10 µM) on the activities of PKC, p38, PDGFRβ, or EGFR. Inhibits the proliferation of growth factor-stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F.
      Catalogue Number572650
      Brand Family Calbiochem®
      Synonyms3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one
      References
      ReferencesYu, B., et al. 2002. Biochem. Pharmacol. 64, 1091.
      Lane, M.E., et al. 2001. Cancer Res. 61, 6170.
      Product Information
      CAS number666837-93-0
      ATP CompetitiveY
      FormYellow to orange solid
      Hill FormulaC₁₃H₁₁N₃O₂
      Chemical formulaC₁₃H₁₁N₃O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdk2/A
      Primary Target IC<sub>50</sub>22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      572650-5MG 04055977266313

      Documentation

      SU9516 - CAS 666837-93-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      SU9516 - CAS 666837-93-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      572650

      References

      Reference overview
      Yu, B., et al. 2002. Biochem. Pharmacol. 64, 1091.
      Lane, M.E., et al. 2001. Cancer Res. 61, 6170.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      Synonyms3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one
      DescriptionA cell-permeable, 3-substituted indolinone compound that displays anti-proliferative and pro-apoptotic properties in tumor cells. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks) (IC50 = 22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1). Exhibits no significant effect on the activities of PKC, p38, PDGFRβ, or EGFR (IC50 >10 µM). Reported to inhibit the proliferation of growth factor-stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F.
      FormYellow to orange solid
      CAS number666837-93-0
      Chemical formulaC₁₃H₁₁N₃O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesYu, B., et al. 2002. Biochem. Pharmacol. 64, 1091.
      Lane, M.E., et al. 2001. Cancer Res. 61, 6170.