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573099 Sigma-AldrichSTAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem

STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents its association with upstream Kinases.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Brochures
Technical Information
Data Sheet

Synonyms: 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound

Primary Target: STAT3

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Overview

Key Spec Table

CAS #	Empirical Formula
19983-44-9	C₈H₅NO₄S

Pricing & Availability

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Description
Overview	A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr⁷⁰⁵ with little effect towards STAT1 phosphorylation at Tyr⁷⁰¹ (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).
Catalogue Number	573099
Brand Family	Calbiochem®
Synonyms	6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound

References
References	Schust, J., et al. 2006. Chem. Biol. 13, 1235.

Product Information
CAS number	19983-44-9
ATP Competitive	N
Form	Pale yellow solid
Hill Formula	C₈H₅NO₄S
Chemical formula	C₈H₅NO₄S
Reversible	N
Structure formula Image
Quality Level	MQ100

Biological Information
Primary Target	STAT3
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Global Trade Item Number
Catalogue Number	GTIN
573099-25MG	07790788051754

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