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565851 SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem

SHP1/2 PTPase Inhibitor, NSC-87877, CAS 56932-43-5, is a cell-permeable, potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 tyrosine phosphatases (IC50 = 355 nM & 318 nM, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I

Primary Target: SHP1/2 PTPase
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565851
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
56932-43-5C₁₉H₁₁N₃Na₂O₇S₂

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      Description
      OverviewA cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC50 = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC50 = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.
      Catalogue Number565851
      Brand Family Calbiochem®
      Synonyms8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I
      References
      ReferencesChen, L., et al. 2006. Mol. Pharmacol. 70, 562.
      Product Information
      CAS number56932-43-5
      ATP CompetitiveN
      FormRedish brown solid
      Hill FormulaC₁₉H₁₁N₃Na₂O₇S₂
      Chemical formulaC₁₉H₁₁N₃Na₂O₇S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationSHP1/2 PTPase Inhibitor, NSC-87877, CAS 56932-43-5, is a cell-permeable, potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 tyrosine phosphatases (IC50 = 355 nM & 318 nM, respectively).
      Biological Information
      Primary TargetSHP1/2 PTPase
      Primary Target IC<sub>50</sub>355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      565851-50MG 04055977191271

      Documentation

      SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      565851

      References

      Reference overview
      Chen, L., et al. 2006. Mol. Pharmacol. 70, 562.

      Brochure

      Title
      An Introduction to Inhibitors and Their Biological Applications - 1st Edition
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2008 RFH
      Synonyms8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I
      DescriptionA cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC50 = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC50 = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.
      FormRedish brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number56932-43-5
      Chemical formulaC₁₉H₁₁N₃Na₂O₇S₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityH₂O (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesChen, L., et al. 2006. Mol. Pharmacol. 70, 562.