540216 Sigma-AldrichPTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem
The PTP Inhibitor XVIII, also referenced under CAS 1229246-07-4, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation ap
More>> The PTP Inhibitor XVIII, also referenced under CAS 1229246-07-4, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Protein Tyrosine Phosphatase Inhibitor XIII, 5-(E)-(2-(3,5-Ditrifluoromethylbenzyloxy)-5-bromo)-benzylidene-1,3-thiazolane-2,4-dione, PPAR Activator VII
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 1229246-07-4 | C₁₉H₁₀BrF₆NO₃S |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 540216-10MG |
|
Plastic ampoule | 10 mg |
|
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| Description | |
|---|---|
| Overview | A cell-permeable thiazolidinedione compound that is shown to inhibit the enzymatic activity of PTP1B, SHP-1, YOP, TC-PTP, and YPTP1 (IC50 = 5, 5.8, 6, 16, and 18 µM, respectively), but not that of LAR even at concentrations as high as 100 µM. Also reported to activate cellular PPAR with an comparable potency seen with troglitazone (Cat. No. 648469). The combined effect of PTP1B inhibition and PPAR activation most likely accounts for the compound's in vivo antiobesity and antihypoglycemic activity when supplemented directly into the daily high fat diet of C57BL/6j jms Slc male mice (2 mg/g food, ~143 mg/kg animal weight or 4.8 mg/animal). |
| Catalogue Number | 540216 |
| Brand Family | Calbiochem® |
| Synonyms | Protein Tyrosine Phosphatase Inhibitor XIII, 5-(E)-(2-(3,5-Ditrifluoromethylbenzyloxy)-5-bromo)-benzylidene-1,3-thiazolane-2,4-dione, PPAR Activator VII |
| References | |
|---|---|
| References | Bhattarai, B.R., et al. 2009. Bioorg. Med. Chem. Lett. 19, 6161. |
| Product Information | |
|---|---|
| CAS number | 1229246-07-4 |
| Form | Light yellow powder |
| Hill Formula | C₁₉H₁₀BrF₆NO₃S |
| Chemical formula | C₁₉H₁₀BrF₆NO₃S |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥95% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 540216-10MG | 04055977268706 |