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474780 MG-115 - CAS 133407-86-0 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
133407-86-0C₂₅H₃₉N₃O₅

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474780-5MG
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      Description
      OverviewPotent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively). Specifically inhibits the chymotrypsin-like activity of the proteasome and induces apoptosis in Rat-1 and PC12 cells.
      Catalogue Number474780
      Brand Family Calbiochem®
      SynonymsCarbobenzoxy-L-leucyl-L-leucyl-L-norvalinal, Z-LL-Nva-CHO, Proteasome Inhibitor XII
      References
      ReferencesLopes, U.G., et al. 1997. J. Biol. Chem. 272, 12893.
      Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem. 271, 27280.
      Palombella, V.J., et al. 1994. Cell 78, 773. Rock, K.L., et al. 1994. Cell 78, 761.
      Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
      Product Information
      CAS number133407-86-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₅H₃₉N₃O₅
      Chemical formulaC₂₅H₃₉N₃O₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Target20S proteasome
      Primary Target K<sub>i</sub>21 nM and 35 nM for 20S and 26S proteasome, respectively
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceZ-Leu-Leu-Nva-CHO
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      474780-5MG 04055977185447