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SCC138 LAMA-87 Human Chronic Myeloid Leukemia Cell Line

The LAMA-87 human chronic myeloid leukemia cell line is useful for studying the molecular regulation of pluripotent cell commitment and provide a useful tool for hematopoiesis studies.

SCC138
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC138
      DescriptionLAMA-87 Human Chronic Myeloid Leukemia Cell Line
      OverviewThe LAMA-87 human chronic myeloid leukemia cell line is an erythroeosinophilic cell line derived from LAMA-84 (2). LAMA-87 cells are positive for the BCR-ABL gene translocation (3) and express erythrocytic markers such as glycophorin A, as well as the CD33 granulomonocytic marker CD33, which distinguishes CML from other leukemias (2). When inoculated into non-treated athymic mice, LAMA-87 cells can differentiate to give rise to eosinomonocytic cells (2).

      Source:
      The LAMA-87 cell line was derived from LAMA-84 human chronic myeloid leukemia cells inoculated into estrone-treated athymic mice (2). The parent LAMA-84 cell line was isolated from leukemia of a 29-year-old female patient (3).
      Alternate Names
      • LAMA87
      Background InformationChronic Myeloid Leukemia (CML) is a cancer arising from B cells in the bone marrow. CML is a relatively rare childhood leukemia and represents approximately 15% of adult leukemias (1). Progression of the disease is slow but terminates in blast crisis, during which the B cells exhibit uncontrolled hyper-proliferation. Cellular models at this stage of CML are valuable for studies of B cell research owing to their immortal phenotype and rapid proliferation.

      References:
      1. Leukemia. 2019; 33(7): 1543-1566.
      2. Leuk Res. 1994; 18(12): 903-918.
      3. Exp Hematol. 1987; 15(8): 822-832.
      References
      Product Information
      Applications
      ApplicationThe LAMA-87 human chronic myeloid leukemia cell line is useful for studying the molecular regulation of pluripotent cell commitment and provide a useful tool for hematopoiesis studies.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC138 04061841074939

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