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508409 InSolution™ Bafilomycin A1, ≥97% by HPLC - CAS 88899-55-2 - Calbiochem

This product can no longer be ordered through emdmillipore.com. Please refer to (Cat. No. 508409) on sigmaaldrich.com.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Bafilomycin A1, ≥97% by HPLC InSolution

Primary Target: vacuolar-type H+-ATPase
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508409
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
88899-55-2C₃₅H₅₈O₉

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      Description
      Catalogue Number508409
      Brand Family Calbiochem®
      SynonymsBafilomycin A1, ≥97% by HPLC InSolution
      References
      ReferencesSinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
      Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
      Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
      Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
      Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
      Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
      Drose, S., et al. 1993. Biochemistry 32, 3902.
      Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
      Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.
      Product Information
      CAS number88899-55-2
      FormLiquid
      FormulationA 100 µM (15 µg/241 µL) sterile-filtered solution of Bafilomycin A1, ≥97% by HPLC in 90% DMSO.
      Hill FormulaC₃₅H₅₈O₉
      Chemical formulaC₃₅H₅₈O₉
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetvacuolar-type H+-ATPase
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 1 year at -20°C. Use only fresh DMSO for further dilutions.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5084090001 04055977261936

      Documentation

      InSolution™ Bafilomycin A1, ≥97% by HPLC - CAS 88899-55-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
      Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
      Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
      Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
      Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
      Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
      Drose, S., et al. 1993. Biochemistry 32, 3902.
      Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
      Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-April-2014 JSW
      SynonymsBafilomycin A1, ≥97% by HPLC InSolution
      DescriptionA macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 0.5 nM) and is a valuable tool for distinguishing among different types of ATPases. Reported to selectivity inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). Blocks lysosomal cholesterol trafficking in macrophages. Known to interfere with pH regulation in brain cells. Inhibits bone resorption both in vivo and in vitro. Has been shown to exhibit cytotoxic effects on a number of cell lines in a cell viability assay.
      FormLiquid
      FormulationA 100 µM (15 µg/241 µL) sterile-filtered solution of Bafilomycin A1, ≥97% by HPLC in 90% DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number88899-55-2
      Chemical formulaC₃₅H₅₈O₉
      Purity≥97% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 1 year at -20°C. Use only fresh DMSO for further dilutions.
      Toxicity Standard Handling
      ReferencesSinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
      Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
      Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
      Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
      Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
      Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
      Drose, S., et al. 1993. Biochemistry 32, 3902.
      Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
      Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.