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407621 IL-2Rα Antagonist - CAS 1217448-66-2 - Calbiochem

The IL-2Rα Antagonist, also referenced under CAS 1217448-66-2, controls the biological activity of IL-2Rα.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (R)-N-(2-(1-(Aminoiminomethyl)-3-piperidinyl)-1-oxoethyl)-4-(phenylethynyl)-L-phenylalanine methyl ester, trifluoroacetate, Ro26-4550

Primary Target: Inhibitor of the IL-2/IL-2Rα interaction
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407621
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Overview

Key Spec Table

CAS #Empirical Formula
1217448-66-2C₂₆H₃₀N₄O₃ • CF₃CO₂H

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407621-5MG
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      Description
      OverviewA non-peptidyl acylphenylalanine compound that binds to IL-2 and acts as a competitive inhibitor of the IL-2/IL-2Rα interaction (IC50 = 3 µM).
      Catalogue Number407621
      Brand Family Calbiochem®
      Synonyms(R)-N-(2-(1-(Aminoiminomethyl)-3-piperidinyl)-1-oxoethyl)-4-(phenylethynyl)-L-phenylalanine methyl ester, trifluoroacetate, Ro26-4550
      References
      ReferencesEmerson, S.D., et al. 2003. Protein Science 12, 811.
      Tilley, J.W., et al. 1997. J. Am. Chem. Soc. 119, 7589.
      Product Information
      CAS number1217448-66-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₆H₃₀N₄O₃ • CF₃CO₂H
      Chemical formulaC₂₆H₃₀N₄O₃ • CF₃CO₂H
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetInhibitor of the IL-2/IL-2Rα interaction
      Primary Target IC<sub>50</sub>3 µM against IL-2/IL-2Rα interaction
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      407621-5MG 04055977211368