Millipore Sigma Vibrant Logo

361566 GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: SB-216763

View Products on Sigmaaldrich.com
361566
View Pricing & Availability

Overview

Key Spec Table

CAS #Empirical Formula
280744-09-4C₁₉H₁₂Cl₂N₂O₂

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
361566-10MG
—
Fulfillment and delivery delayed Fulfillment and delivery delayed
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Glass bottle 10 mg
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Add To Favorites
      Description
      OverviewA cell-permeable (aryl,indole) maleimide compound that acts as a potent, selective, ATP-competitive inhibitor of GSK-3 activity (Ki = 9.1 nM for GSK-3α). At 10 µM concentration, does not significantly inhibit a panel of 24 other protein kinases tested. Reported to stimulate glycogen synthesis in Chang human liver cells (EC50 = 3.6 µM) and induce transcription of β-catenin-LEF/TCF (lymphoid enhancer factor/T cell factor) regulated reporter gene in HEK293 human embryonic kidney cell lines. Offers protection against polyglutamine-induced death in SK-N-SH and COS-7 cells and attenuates hypoxia-induced apoptosis in VSMC and COS-7 cells. Shown to reduce phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) expression in hepatoma cells. Promotes the survival of CLL lymphocytes via Wnt/β-catenin-mediated transcription activation. Exhibits delayed cardioprotection in vivo in a rat model via a KATP (ATP-sensitive potassium channels) and MPTP (mitochondrial permeability transition pore)-dependent mechanism at reperfusion.
      Catalogue Number361566
      Brand Family Calbiochem®
      SynonymsSB-216763
      References
      ReferencesGross, E., et al. 2008. Am. J. Phy. Heart Circ Physiol. 294, H1497.
      Bain, J., et al. 2007. Biochem. J. 408, 297.
      Lu, D., et al. 2004. PNAS. 101, 3118.
      Carmichael, J., et al. 2002. J. Biol. Chem. 277, 33791.
      Culbert, A.A., et al. 2001. FEBS Lett. 507, 288.
      Lochhead, P.A., et al. 2001. Diabetes 50, 937.
      Cross, D.A., et al. 2001. J. Neurochem. 77, 94.
      Coghlan, M.P., et al. 2000. Chem. Biol. 7, 793.
      Product Information
      CAS number280744-09-4
      FormOrange solid
      Hill FormulaC₁₉H₁₂Cl₂N₂O₂
      Chemical formulaC₁₉H₁₂Cl₂N₂O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥98% by HPLC
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      361566-10MG 04055977214246