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317700 Dkk-1 Inhibitor, WAY-262611, HCl - Calbiochem

Overview

Key Spec Table

Empirical Formula
C₂₀H₂₂N₄ • HCl

Pricing & Availability

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317700-10MG
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      Description
      OverviewA 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC50 = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo.
      Catalogue Number317700
      Brand Family Calbiochem®
      Synonyms(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI
      References
      ReferencesPelletier, J.C., et al. 2009. J. Med. Chem. 52, 6962.
      Product Information
      FormYellow powder
      FormulationSupplied as a hydrochloride salt.
      Hill FormulaC₂₀H₂₂N₄ • HCl
      Chemical formulaC₂₀H₂₂N₄ • HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationDkk-1 Inhibitor, WAY-262611, HCl, CAS 1123231-07-1, counteracts the antagonizing effect of Dkk-1 against Wnt-3a/LRP5 interaction. Prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation.
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      317700-10MG 04055977216288