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298711 Diethyl Pyrocarbonate - CAS 1609-47-8 - Calbiochem

Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Diethyl Oxydiformate, DEPC

Primary Target: Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle
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298711
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Overview

Key Spec Table

CAS #Empirical Formula
1609-47-8C₆H₁₀O₅

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298711-100GM
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      298711-25GM
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          Description
          OverviewInhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
          Catalogue Number298711
          Brand Family Calbiochem®
          SynonymsDiethyl Oxydiformate, DEPC
          References
          ReferencesShoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
          Blumbers, D.O. 1987. Methods Enzymol. 152, 20.
          Product Information
          CAS number1609-47-8
          ATP CompetitiveN
          FormClear colorless liquid
          Hill FormulaC₆H₁₀O₅
          Chemical formulaC₆H₁₀O₅
          ReversibleN
          Quality LevelMQ100
          Biological Information
          Primary TargetInhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle
          Purity≥96% by titration
          Physicochemical Information
          Cell permeableN
          Safety Information according to GHS
          RTECSLQ9350000
          Safety Information
          R PhraseR: 22-36/37/38

          Harmful if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Global Trade Item Number
          Catalogue Number GTIN
          298711-100GM 04055977197952
          298711-25GM 07790788049041