What has senescence got to do with cancer? Dimri, Goberdhan P Cancer Cell, 7: 505-12 (2005)
2005
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Cancer therapeutics are primarily thought to work by inducing apoptosis in tumor cells. However, various tumor suppressors and oncogenes have been shown to regulate senescence in normal cells, and senescence bypass appears to be an important step in the development of cancer. Cellular senescence limits the replicative capacity of cells, thus preventing the proliferation of cells that are at different stages of malignancy. A recent body of evidence suggests that induction of senescence can be exploited as a basis for cancer therapy. | 15950900
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Replicative senescence revisited. Marcotte, Richard and Wang, Eugenia J. Gerontol. A Biol. Sci. Med. Sci., 57: B257-69 (2002)
2002
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Forty years after its discovery, replicative senescence remains a rich source of information about cell-cycle regulation and the progression from a normal to a transformed phenotype. Effectors of this growth-arrested state are being discovered at a great pace. This review discusses the latest findings on the players responsible for establishing replicative senescence, as well as the associated telomere shortening. | 12084796
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