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219415 Cathepsin Inhibitor I - Calbiochem

Overview

Key Spec Table

Empirical Formula
C₂₆H₂₅N₃O₆

Pricing & Availability

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219415-1MG
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      Description
      OverviewCell-permeable cysteine protease inhibitor. Inhibits cathepsin B (k2/Ki = 8.9 x 103 M-1 sec-1), cathepsin L (k2/Ki = 3.8 x 105 M-1 sec-1), cathepsin S (k2/Ki = 4.2 x 104 M-1 sec-1), and papain (k2/Ki = 2.4 x 103 M-1 sec-1).
      Half-life in buffered solution (pH 5-9) = 25 h (30°C); 300 h (0°C).
      Catalogue Number219415
      Brand Family Calbiochem®
      SynonymsZ-FG-NHO-Bz, CATI -1
      References
      ReferencesZhu, D. and Uckun, F.M. 2000. Clin. Cancer Res. 6, 2064.
      Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
      Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₆H₂₅N₃O₆
      Chemical formulaC₂₆H₂₅N₃O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetcathepsin B
      Primary Target K<sub>i</sub>k₂/Ki = 8.9 x 10³ M⁻¹sec⁻¹ for cathepsin B
      Purity>90% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Phe-Gly-NHO-Bz
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      219415-1MG 04055977218329