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SCT055 BioTracker Cys Hcy GSH Live Cell Dye Probe1

Live cell imaging dye to simultaneously report for cellular levels of Glutathione (GSH), Cysteine (Cys) and Homocysteine (Hcy) which are inter-related and implicated in several diseases.

SCT055
1 mg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCT055
      DescriptionBioTracker Cys Hcy GSH Live Cell Dye Probe1
      OverviewBiological thiols, such as cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), play crucial roles in many physiological and pathological processes. GSH is the most abundant intracellular thiol and plays a central role in combating oxidative stress. Cys is an essential amino acid that is involved in protein synthesis, detoxication, and metabolism. Suboptimal levels of GSH and Cys is involved in several diseases. Elevated plasma total Hcy levels have been established as an independent risk factor for cardiovascular diseases, Alzheimer's disease, neural tube defects, and other diseases.

      The BioTracker Cys Hcy GSH triple live cell dye can be used for simultaneous detection of GSH and Cys/Hcy in living cells and tissues. GSH is detected in the red channel while Cys/Hcy are detected in the blue channel.

      Spectral Properties
      Absorption: 365 nm
      Emissions: GSH detection: 587 nm
      Emissions: Cys/Hcy detection: 454 nm

      References
      Yang XF et al. A dual emission fluorescent probe enables simultaneous detection of glutathione and
      cysteine/homocysteine. Chem. Sci., 2014, 5, 2177.
      Alternate Names
      • Live cell imaging probe
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized
      Applications
      ApplicationLive cell imaging dye to simultaneously report for cellular levels of Glutathione (GSH), Cysteine (Cys) and Homocysteine (Hcy) which are inter-related and implicated in several diseases.
      Key Applications
      • Cell Based Assays
      Application NotesLive cell fluorescent imaging
      Biological Information
      ConcentrationPlease refer to lot specific datasheet.
      Molecular Weight706.68 g/mol
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity: ≥ 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
      Molar Mass: 706.68 g/mol
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore BioTracker Cys Hcy GSH Live Cell Dye at -20°C, desiccate and protect from light
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCT055 04054839008436