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196440 Batimastat - CAS 130370-60-4 - Calbiochem

Batimastat, CAS 130370-60-4, is a potent inhibitor of a several metalloproteinases, including MMP-1, 2, 3, 7, 9, ΔMT1, ADAM8 & ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3 & 19 nM, respectiv

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Batimastat - CAS 130370-60-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide, BB-94

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196440
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Overview

Key Spec Table

CAS #Empirical Formula
130370-60-4C₂₃H₃₁N₃O₄S₂

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      Description
      OverviewA Marimastat (Cat. No. 444289) type of peptidyl hydroxamate-based inhibitor that potently inhibits a broad-spectrum of metalloproteinases, including MMP-1, MMP-2, MMP-3/stromelysin, MMP-7/matrilysin, MMP-9, ΔMT1 (MMP-14 without TM domain), ADAM8, and ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3, and 19 nM, respectively), by targeting both the substrate binding site and the active-site Zn2+, while being much less potent toward ACE (Angiotensin Converting Enzyme) or α-secretase (IC50 = 1.6 and 3.3 µM, respectively). Batimastat is widely used in studying the involvement of MMPs in cancinogenesis and non-cancer pathological processes both in cultures in vitro and in animals in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 508408).
      Catalogue Number196440
      Brand Family Calbiochem®
      Synonyms(4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide, BB-94
      References
      ReferencesSchlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
      Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
      Parvathy, S., et al. 1998. Biochemistry 37, 1680.
      Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
      Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
      Moss, M.L., et al. 1997. Nature 385, 733.
      Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
      Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
      Wang, X., et al. 1994. Cancer Res. 54, 4726.
      Davies, B., et al. 1993. Cancer Res. 53, 2087.
      Product Information
      CAS number130370-60-4
      FormOff-white solid
      Hill FormulaC₂₃H₃₁N₃O₄S₂
      Chemical formulaC₂₃H₃₁N₃O₄S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationBatimastat, CAS 130370-60-4, is a potent inhibitor of a several metalloproteinases, including MMP-1, 2, 3, 7, 9, ΔMT1, ADAM8 & ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3 & 19 nM, respectively).
      Biological Information
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      196440-5MG 04055977206500