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ABE1341-25UL Anti-ZBTB38

Anti-ZBTB38 Antibody, Cat. No. ABE1341, is a highly specific rabbit polyclonal antibody that targets ZBTB38 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-ZBTB38 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Gene Symbol: ZBTB38 UniProt Number: Q8NAP3
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ABE1341-25UL
25 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)RbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1341-25UL
      DescriptionAnti-ZBTB38
      Alternate Names
      • Zinc finger and BTB domain-containing protein 38
      Background InformationZinc finger and BTB domain-containing protein 38 (UniProt: Q8NAP3, ZBTB38) is encoded by the ZBTB38 gene (Gene ID: 253461) in human. ZBTB38 is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', but can also bind to E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair and represses transcription in a methyl-CpG-dependent manner. ZBTB38 protein is reported to play an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner and is shown to repress expression of MCM10, which plays an important role in DNA-replication. It is also believed to be involved in the differentiation and/or survival of late post-mitotic neurons. ZBTB38 protein contains ten C2H2-type zinc fingers and its BTB (Broad-Complex, Tramtrack and Bric a brac) domain is localized in the amino acids 33-100. However, the BTB domain is not required for its activation. ZBTB38 is down-regulated under conditions of endoplasmic reticulum (ER) stress, which promotes ER stress-associated apoptosis in human bone marrow neuroblastoma cells. In mice subjected to spinal cord injury (SCI) a repression of ZBTB38 is observed and this is linked to reduced secondary tissue damage after SCI. (Ref.:Cai, Y., et al. (2017). Oncotarget 8(28); 45356-45366).
      References
      Product Information
      FormatPurified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-ZBTB38 Antibody, Cat. No. ABE1341, is a highly specific rabbit polyclonal antibody that targets ZBTB38 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected ZBTB38 in human testis and human kidney tissue sections.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 20 amino acids from the C-terminus region of human Zinc finger and BTB domain-containing protein 38.
      EpitopeC-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis rabbit polyclonal antibody specifically detects Zinc finger and BTB domain-containing protein 38 in human cells. It targets an epitope within 20 amino acids from the C-terminus region.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ZBTB38
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight~170 kDa observed; 134.26 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell nuclear extract.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected ZBTB38 in HeLa cell nuclear extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE1341-25UL 04054839448201