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AB5574-50UL Anti-TrpC6 Antibody

Anti-TrpC6 Antibody is an antibody against TrpC6 for use in IH & WB.

Anti-TrpC6 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: TRPC6, FLJ11098, FSGS2, TrpC6, FLJ14863, TRP6 UniProt Number: Q9Y210
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AB5574-50UL
50 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RIHC, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5574-50UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-TrpC6 Antibody
      Alternate Names
      • Transient Receptor Potential-Like Channel 6
      • Trp6
      References
      Product Information
      FormatAffinity Purified
      Control
      • CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
      PresentationAffinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
      Quality LevelMQ100
      Applications
      ApplicationAnti-TrpC6 Antibody is an antibody against TrpC6 for use in IH & WB.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot:1:200-1:400 using ECL on rat brain membranes.
      Immunohistochemstry on mouse brain sections.
      Dilutions should be made using a carrier protein such as BSA (1-3%)
      Addition of 0.1-0.5% Tween-20 to the antibody solution is recommended.
      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenPeptide corresponding to amino acids 24-38 from mouse TRPC6 (Zhu et al. 1996). Accession Q61143
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes TRPC6 (Transient Receptor Potential-Like Channel 6, TRP-6). Does not cross react with any other known proteins.

      SPECIES REACTIVITIES: It is expected that the antibody will also work on human due to sequence conservation (15/16). Other species have not been tested.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TRPC6
      • FLJ11098
      • FSGS2
      • TrpC6
      • FLJ14863
      • TRP6
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9Y210 # Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
      SIZE: 931 amino acids; 106326 Da
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable).
      TISSUE SPECIFICITY: Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.
      DISEASE: SwissProt: Q9Y210 # Defects in TRPC6 are the cause of focal segmental glomerulosclerosis 2 (FSGS2) [MIM:603965]. FSGS2 is an autosomal dominant disease characterized by increased urinary protein excretion (proteinuria) and decreasing kidney function (nephrotic syndrome). Renal insufficiency often progresses to end-stage renal disease (ESRD) (also known as end-stage renal failure), a highly morbid state requiring either dialysis therapy or kidney transplantation.
      SIMILARITY: SwissProt: Q9Y210 ## Belongs to the transient receptor family. STrpC subfamily. & Contains 4 ANK repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5574-50UL 04053252587306

      Documentation

      Anti-TrpC6 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-TrpC6 Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-TRPC6 (Transient Receptor Potential-Like Channel 6, TRP-6) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2075088 2075088
      RABBIT ANTI-TRPC6 (Transient Receptor Potential-Like Channel 6, TRP-6) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2393851 2393851
      RABBIT ANTI-TRPC6 (Transient Receptor Potential-Like Channel 6, TRP-6) - 3902932 3902932
      RABBIT ANTI-TRPC6 (Transient Receptor Potential-Like Channel 6, TRP-6) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2122409 2122409
      RABBIT ANTI-TRPC6 (Transient Receptor Potential-Like Channel 6, TRP-6) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2283793 2283793
      RABBIT ANTI-TRPC6 - 3792849 3792849
      RABBIT ANTI-TRPC6 - 4119728 4119728
      RABBIT ANTI-TRPC6 -2648193 2648193
      RABBIT ANTI-TRPC6 -2710265 2710265
      RABBIT ANTI-TRPC6 -2793679 2793679

      Data Sheet

      Title
      RABBIT ANTI-TRPC6 (Transient Receptor Potential-Like Channel 6, TRP-6) AFFINITY PURIFIED, POLYCLONAL ANTIBODY