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ABN471 Anti-TMEM18 Antibody

Anti-TMEM18 Antibody is a highly specific rabbit polyclonal antibody, that targets TMEM18 & has been tested in western blotting, IHC & Immunofluorescence.

Anti-TMEM18 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Sensory & PNS Gene Symbol: TMEM18 UniProt Number: Q96B42
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ABN471
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, MWB, IHC, IFRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN471
      DescriptionAnti-TMEM18 Antibody
      Alternate Names
      • Transmembrane protein 18
      • TMEM18
      Background InformationTransmembrane protein 18 (TMEM18) is a transcription repressor and cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC). Recent studies have shown that overexpression of TMEM18 provides NSCs and neural precursors an increased migration capacity towards glioblastoma cells, while functional inactivation of the gene resulted in an almost complete loss of migration activity. This evidence implies that TMEM18 could be a potential target in NSC-based glioma therapy. Other studies suggest that TMEM18 loci is associated with higher than normal body mass index (BMI) and obesity, and may play a CNS-related role in predisposition to obesity.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Rat brain tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-TMEM18 Antibody is a highly specific rabbit polyclonal antibody, that targets TMEM18 & has been tested in western blotting, IHC & Immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected TMEM18 in mouse brain tissue.

      Immunofluorescence Analysis: 20 μg/mL from a representative lot detected TMEM18 in mouse brain tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human TMEM18.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Rat
      • Mouse
      Species Reactivity NoteDemonstrated to react with Mouse and Rat. Predicted to react with Human based on immunogen design.
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • TMEM18
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~27 kDa observed. Uniprot describes 2 isoforms at ~15 kDa and ~16 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat brain tissue lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected TMEM18 in 15 µg of rat brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN471 04053252910159