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ABS1016 Anti-PAS Kinase Antibody

Anti-PAS Kinase Antibody is an antibody against PAS Kinase for use in Western Blotting, Immunohistochemistry .

Anti-PAS Kinase Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: PASK, KIAA0135 UniProt Number: Q96RG2
ABS1016
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABS1016
      DescriptionAnti-PAS Kinase Antibody
      Alternate Names
      • PAS domain-containing serine/threonine-protein kinase
      • PAS Kinase
      • PAS-kinase
      • PASKIN
      • hPASK
      Background InformationPAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1; UniProt Q96RG2; also known as hPASK, PASKIN, PAS-kinase, Per-arnt-sim domain kinase) is encoded by the PASK (Also known as KIAA0135, STK37) gene in human (Gene ID 23178). PAS-kinase is a serine/threonine-protein kinase involved in energy homeostasis. Hepatic PASK expression is shown to be induced upon feeding and insulin stimulation, and PASK is reported to be essential for the proteolytic maturation of the transcription factor SREBP-1c in cultured cells and in the mouse and rat liver. SREBP-1c hyperactivation leads to excess hepatic fatty acids and triglycerides synthesis, which has been implicated as a causal feature of metabolic syndrome. PASK inhibition improves lipid and glucose metabolism in dietary animal models of obesity and dyslipidemia. PASK is also involved in protein translation regulation and is shown to phosphorylate eukaryotic translation elongation factor eEF1A1.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationAnti-PAS Kinase Antibody is an antibody against PAS Kinase for use in Western Blotting, Immunohistochemistry .
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected PAS Kinase in rat testis tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human PAS Kinase near the C-terminus.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis antibody is expected to detect all three splced isoforms.
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PASK
      • KIAA0135
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~160 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HEK293 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected PAS Kinase in 50 µg of HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABS1016 04055977169966