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ABC67 Anti-Mitochondrial fission 1 protein (Fis1) Antibody

Detect Mitochondrial fission 1 protein (Fis1) using this Anti-Mitochondrial fission 1 protein (Fis1) Antibody validated for use in WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: FIS1, TTC11, CGI-135 UniProt Number: Q9Y3D6
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ABC67
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC67
      DescriptionAnti-Mitochondrial fission 1 protein (Fis1) Antibody
      Alternate Names
      • FIS1 homolog
      • hFis1
      • Tetratricopeptide repeat protein 11
      • TPR repeat protein 11
      Background InformationMitochondrial fission 1 protein, hFIs1, is an overexpressed mammlian protein that is localized to the outer mitochondrial membrane of various cell types. It is involved in the fragmentation of the mitochondrial network and its perinuclear clustering, resulting in the release of cytochrome c from the mitochondrion, and apopotosis. It is known to mediate peroxisomal fission and also plays a critical role in histone function by demethylating Lys-4 of histone H3.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Raji cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Mitochondrial fission 1 protein (Fis1) using this Anti-Mitochondrial fission 1 protein (Fis1) Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated-linear peptide corresponding to the cytoplasmic topological domain of human Mitochondrial fission 1 protein.
      EpitopeCytoplasmic topological domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the cytoplasmic topological domain of Mitochondrial fission 1 protein.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with Human.
      Other homologies: Rat and Mouse (83% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission.
      Gene Symbol
      • FIS1
      • TTC11
      • CGI-135
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.

      SUBUNIT STRUCTURE: Interacts with DNM1L/DLP1 through the TPR region. Interacts with MARCH5.

      SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
      Molecular Weight~17 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in Raji cell lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Mitochondrial fission 1 protein in 10 µg of Raji cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABC67 04053252633911

      Documentation

      Anti-Mitochondrial fission 1 protein (Fis1) Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Mitochondrial fission 1 protein (Fis1) Antibody Certificates of Analysis

      TitleLot Number
      Anti-Mitochondrial fission 1 protein (Fis1) - 2420613 2420613
      Anti-Mitochondrial fission 1 protein (Fis1) - 2279247 2279247
      Anti-Mitochondrial fission 1 protein (Fis1) - 2300020 2300020
      Anti-Mitochondrial fission 1 protein (Fis1) - 3160185 3160185
      Anti-Mitochondrial fission 1 protein (Fis1) - 3205925 3205925
      Anti-Mitochondrial fission 1 protein (Fis1) - 3271978 3271978
      Anti-Mitochondrial fission 1 protein (Fis1) - NRG1944667 NRG1944667
      Anti-Mitochondrial fission 1 protein (Fis1) -2676697 2676697
      Anti-Mitochondrial fission 1 protein (Fis1) -2891879 2891879
      Anti-Mitochondrial fission 1 protein (Fis1) Polyclonal Antibody 2962975
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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies