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ABF317 Anti-MICA Antibody

This Anti-MICA Antibody is validated for use in Western Blotting_x000D_ and Immunohistochemistry for the detection of MICA.

Anti-MICA Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: MICA, PERB11.1 UniProt Number: Q29983
ABF317
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABF317
      DescriptionAnti-MICA Antibody
      Alternate Names
      • MHC class I polypeptide-related sequence A
      • MIC-A
      • MICA
      Background InformationThe protein MHC class 1 polypeptide-related sequence A (MIC-A) and encoded by the human gene named MICA is an unusual MHC class one molecule with no known role in antigen presentation but instead acts as a stress-induced self antigen that is recognized by gamma delta T cells and is the ligand for KLRK1/NKG2D cellular receptor. Binding to KLRK1 leads to cell lysis. MICA is a cell membrane associated protein found in the cytoplasm. Additionally, it is expressed in many organ systems and found expressed on many cell types. Expression is induced by many stress responses, including infection, DNA damaging agents, E. coli contact, hCMV and ionizing radiation. MICA is also the antigen for many autoimmune diseases associated with the skin, one organ system where MICA is highly expressed. Psoriasis and Psoriatic arthritis are two such diseases and antibodies to MICA have also been associated with organ transplant difficulties and allograft rejection.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationThis Anti-MICA Antibody is validated for use in Western Blotting_x000D_ and Immunohistochemistry for the detection of MICA.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis (IHC): 10 μg/mL from a representative lot detected MICA in human colon tissue.
      Biological Information
      ImmunogenMICA antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human MICA.
      EpitopeNear C-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • MICA
      • PERB11.1
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~46 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in A-20 cell lysate.

      Western Blotting Analysis (WB): 1 μg/mL of this antibody detected MICA in A-20 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABF317 04055977174656