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ABC822 Anti-LIMP II Antibody

Anti-LIMP II Antibody is an antibody against LIMP II for use in western blotting, IHC & immunofluorescence.

Anti-LIMP II Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: SCARB2, CD36L2, LIMPII UniProt Number: Q14108
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ABC822
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHC, IFRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC822
      DescriptionAnti-LIMP II Antibody
      Alternate Names
      • Lysosome membrane protein 2
      • 85 kDa lysosomal membrane sialoglycoprotein
      • LGP85
      • CD36 antigen-like 2
      • Lysosome membrane protein II
      • LIMP II
      • Scavenger receptor class B member 2
      • CD36
      Background InformationLysosome membrane protein 2, also known as 85 kDa lysosomal membrane sialoglycoprotein (LGP85) or Lysosome membrane protein II (LIMP II) or Scavenger receptor class B member 2, and encoded by the gene name SCARB2 or CD36L2 or LIMPII, is a heavily glycosylated type III transmembrane protein, the majority of which exists in the lumen of the lysosome and a cytoplasmic domain of approximately 20 amino acids. A deficiency of LIMP II in mice causes uretic pelvic junction obstruction, deafness, and peripheral neuropathy associated with impaired vesicular trafficking and distribution of apically expressed proteins. More recently, LIMP II was shown to act as a receptor to bind β-glucocerebrosidase, the enzyme defective in Gaucher disease, a lysosomal storage disorder. LIMP II-deficient mice showed missorted as well as secreted β-glucocerebrosidase, suggesting that LIMP II also functions as the mannose-6-phosphate-independent trafficking receptor.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-LIMP II Antibody is an antibody against LIMP II for use in western blotting, IHC & immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected LIMP II in human skeletal muscle tissue.

      Immunofluorescence Analysis: 20 μg/mL from a representative lot detected LIMP II in human skeletal muscle cells.
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the center region of human LIMP II.
      Epitopecenter region
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • SCARB2
      • CD36L2
      • LIMPII
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~80 kDa observed. Despite its predicted molecular weight, LIMP II runs at approximately 80 – 85 kDa in Western Blotting.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human skeletal muscle tissue lysate with and without blocking peptide.

      Western Blotting Analysis: 1 μg/mL of this antibody detected GPAT-1 in human skeletal muscle tissue lysate with and without blocking peptide.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABC822 04053252943836